---
res:
  bibo_abstract:
  - The maintenance of polygenic variation through a balance between mutation and
    stabilizing selection can be approximated in two ways. In the ‘Gaussian’ approximation,
    a normal distribution of allelic effects is assumed at each locus. In the ‘House
    of Cards’ approximation, the effect of new mutations is assumed to be large compared
    with the spread of the existing distribution. These approximations were developed
    to describe models where alleles may have a continuous range of effects. However,
    previous analyses of models with only two alleles have predicted an equilibrium
    variance equal to that given by the ‘House of Cards’ approximation. These analyses
    of biallelic models have assumed that, at equilibrium, the population mean is
    at the optimum. Here, it is shown that many stable equilibria may coexist, each
    giving a slight deviation from the optimum. Though the variance is given by the
    ‘House of Cards’ approximation when the mean is at the optimum, it increases towards
    a value of the same order as that given by the ‘Gaussian’ approximation when the
    mean deviates from the optimum. Thus, the equilibrium variance cannot be predicted
    by any simple model, but depends on the previous history of the population.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  bibo_doi: 10.1017/S0016672300023156
  bibo_issue: '3'
  bibo_volume: 47
  dct_date: 1986^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0016-6723
  - http://id.crossref.org/issn/1469-5073
  dct_language: eng
  dct_publisher: Cambridge University Press@
  dct_title: The maintenance of polygenic variation through a balance between mutation
    and stabilising selection@
  fabio_hasPubmedId: '3744046'
...