---
res:
  bibo_abstract:
  - Exposure of an isogenic bacterial population to a cidal antibiotic typically fails
    to eliminate a small fraction of refractory cells. Historically, fractional killing
    has been attributed to infrequently dividing or nondividing "persisters."
    Using microfluidic cultures and time-lapse microscopy, we found that Mycobacterium
    smegmatis persists by dividing in the presence of the drug isoniazid (INH). Although
    persistence in these studies was characterized by stable numbers of cells, this
    apparent stability was actually a dynamic state of balanced division and death.
    Single cells expressed catalase-peroxidase (KatG), which activates INH, in stochastic
    pulses that were negatively correlated with cell survival. These behaviors may
    reflect epigenetic effects, because KatG pulsing and death were correlated between
    sibling cells. Selection of lineages characterized by infrequent KatG pulsing
    could allow nonresponsive adaptation during prolonged drug exposure.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Yurichi
      foaf_name: Wakamoto, Yurichi
      foaf_surname: Wakamoto
  - foaf_Person:
      foaf_givenName: Neraaj
      foaf_name: Dhar, Neraaj
      foaf_surname: Dhar
  - foaf_Person:
      foaf_givenName: Remy P
      foaf_name: Chait, Remy P
      foaf_surname: Chait
      foaf_workInfoHomepage: http://www.librecat.org/personId=3464AE84-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-0876-3187
  - foaf_Person:
      foaf_givenName: Katrin
      foaf_name: Schneider, Katrin
      foaf_surname: Schneider
  - foaf_Person:
      foaf_givenName: François
      foaf_name: Signorino Gelo, François
      foaf_surname: Signorino Gelo
  - foaf_Person:
      foaf_givenName: Stanislas
      foaf_name: Leibler, Stanislas
      foaf_surname: Leibler
  - foaf_Person:
      foaf_givenName: John
      foaf_name: Mckinney, John
      foaf_surname: Mckinney
  bibo_doi: 10.1126/science.1229858
  bibo_issue: '6115'
  bibo_volume: 339
  dct_date: 2013^xs_gYear
  dct_identifier:
  - UT:000312985800059
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: Dynamic persistence of antibiotic-stressed mycobacteria@
...