---
res:
  bibo_abstract:
  - The phagocyte NADPH oxidase catalyzes the reduction of O2 to reactive oxygen species
    with microbicidal activity. It is composed of two membrane-spanning subunits,
    gp91-phox and p22-phox (encoded by CYBB and CYBA, respectively), and three cytoplasmic
    subunits, p40-phox, p47-phox, and p67-phox (encoded by NCF4, NCF1, and NCF2, respectively).
    Mutations in any of these genes can result in chronic granulomatous disease, a
    primary immunodeficiency characterized by recurrent infections. Using evolutionary
    mapping, we determined that episodes of adaptive natural selection have shaped
    the extracellular portion of gp91-phox during the evolution of mammals, which
    suggests that this region may have a function in host-pathogen interactions. On
    the basis of a resequencing analysis of approximately 35 kb of CYBB, CYBA, NCF2,
    and NCF4 in 102 ethnically diverse individuals (24 of African ancestry, 31 of
    European ancestry, 24 of Asian/Oceanians, and 23 US Hispanics), we show that the
    pattern of CYBA diversity is compatible with balancing natural selection, perhaps
    mediated by catalase-positive pathogens. NCF2 in Asian populations shows a pattern
    of diversity characterized by a differentiated haplotype structure. Our study
    provides insight into the role of pathogen-driven natural selection in an innate
    immune pathway and sheds light on the role of CYBA in endothelial, nonphagocytic
    NADPH oxidases, which are relevant in the pathogenesis of cardiovascular and other
    complex diseases.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Eduardo
      foaf_name: Tarazona Santos, Eduardo
      foaf_surname: Tarazona Santos
  - foaf_Person:
      foaf_givenName: Moara
      foaf_name: Machado, Moara
      foaf_surname: Machado
  - foaf_Person:
      foaf_givenName: Wagner
      foaf_name: Magalhães, Wagner
      foaf_surname: Magalhães
  - foaf_Person:
      foaf_givenName: Renee
      foaf_name: Chen, Renee
      foaf_surname: Chen
  - foaf_Person:
      foaf_givenName: Fernanda
      foaf_name: Lyon, Fernanda
      foaf_surname: Lyon
  - foaf_Person:
      foaf_givenName: Laurie
      foaf_name: Burdett, Laurie
      foaf_surname: Burdett
  - foaf_Person:
      foaf_givenName: Andrew
      foaf_name: Crenshaw, Andrew
      foaf_surname: Crenshaw
  - foaf_Person:
      foaf_givenName: Cristina
      foaf_name: Fabbri, Cristina
      foaf_surname: Fabbri
  - foaf_Person:
      foaf_givenName: Latife
      foaf_name: Pereira, Latife
      foaf_surname: Pereira
  - foaf_Person:
      foaf_givenName: Laelia
      foaf_name: Pinto, Laelia
      foaf_surname: Pinto
  - foaf_Person:
      foaf_givenName: Rodrigo A
      foaf_name: Fernandes Redondo, Rodrigo A
      foaf_surname: Fernandes Redondo
      foaf_workInfoHomepage: http://www.librecat.org/personId=409D5C96-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-5837-2793
  - foaf_Person:
      foaf_givenName: Ben
      foaf_name: Sestanovich, Ben
      foaf_surname: Sestanovich
  - foaf_Person:
      foaf_givenName: Meredith
      foaf_name: Yeager, Meredith
      foaf_surname: Yeager
  - foaf_Person:
      foaf_givenName: Stephen
      foaf_name: Chanock, Stephen
      foaf_surname: Chanock
  bibo_doi: 10.1093/molbev/mst119
  bibo_issue: '9'
  bibo_volume: 30
  dct_date: 2013^xs_gYear
  dct_identifier:
  - UT:000323616600014
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: 'Evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2,
    and NCF4: Functional implications@'
  fabio_hasPubmedId: '23821607'
...