---
res:
  bibo_abstract:
  - Asymmetries have long been known about in the central nervous system. From gross
    anatomical differences, such as the presence of the parapineal organ in only one
    hemisphere of the developing zebrafish, to more subtle differences in activity
    between both hemispheres, as seen in freely roaming animals or human participants
    under PET and fMRI imaging analysis. The presence of asymmetries has been demonstrated
    to have huge behavioural implications, with their disruption often leading to
    the generation of neurological disorders, memory problems, changes in personality,
    and in an organism's health and well-being. For my Ph.D. work I aimed to tackle
    two important avenues of research. The first being the process of input-side dependency
    in the hippocampus, with the goal of finding a key gene responsible for its development
    (Gene X). The second project was to do with experience-induced laterality formation
    in the hippocampus. Specifically, how laterality in the synapse density of the
    CA1 stratum radiatum (s.r.) could be induced purely through environmental enrichment.
    Through unilateral tracer injections into the CA3, I was able to selectively measure
    the properties of synapses within the CA1 and investigate how they differed based
    upon which hemisphere the presynaptic neurone originated. Having found the existence
    of a previously unreported reversed (left-isomerism) i.v. mutant, through morpholocal
    examination of labelled terminals in the CA1 s.r., I aimed to elucidate a key
    gene responsible for the process of left or right determination of inputs to the
    CA1 s.r.. This work relates to the previous finding of input-side dependent asymmetry
    in the wild-type rodent, where the origin of the projecting neurone to the CA1
    will determine the morphology of a synapse, to a greater degree than the hemisphere
    in which the projection terminates. Using left- and right-isomerism i.v. mice,
    in combination with whole genome sequence analysis, I highlight Ena/VASP-like
    (Evl) as a potential target for Gene X. In relation to this topic, I also highlight
    my work in the recently published paper of how knockout of PirB can lead to a
    lack of input-side dependency in the murine hippocampus. For the second question,
    I show that the environmental enrichment paradigm will lead to an asymmetry in
    the synapse densities in the hippocampus of mice. I also highlight that the nature
    of the enrichment is of less consequence than the process of enrichment itself.
    I demonstrate that the CA3 region will dramatically alter its projection targets,
    in relation to environmental stimulation, with the asymmetry in synaptic density,
    caused by enrichment, relying heavily on commissural fibres. I also highlight
    the vital importance of input-side dependent asymmetry, as a necessary component
    of experience-dependent laterality formation in the CA1 s.r.. However, my results
    suggest that it isn't the only cause, as there appears to be a CA1 dependent mechanism
    also at play. Upon further investigation, I highlight the significant, and highly
    important, finding that the changes seen in the CA1 s.r. were predominantly caused
    through projections from the left-CA3, with the right-CA3 having less involvement
    in this mechanism.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Matthew J
      foaf_name: Case, Matthew J
      foaf_surname: Case
      foaf_workInfoHomepage: http://www.librecat.org/personId=44B7CA5A-F248-11E8-B48F-1D18A9856A87
  bibo_doi: 10.15479/AT:ISTA:th_1032
  dct_date: 2018^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2663-337X
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_title: 'From the left to the right: A tale of asymmetries, environments, and
    hippocampal development@'
...