---
_id: '514'
abstract:
- lang: eng
  text: 'Orientation in space is represented in specialized brain circuits. Persistent
    head direction signals are transmitted from anterior thalamus to the presubiculum,
    but the identity of the presubicular target neurons, their connectivity and function
    in local microcircuits are unknown. Here, we examine how thalamic afferents recruit
    presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic
    interactions between these cells. Pyramidal neuron activation of Martinotti cells
    in superficial layers is strongly facilitating such that high-frequency head directional
    stimulation efficiently unmutes synaptic excitation. Martinotti-cell feedback
    plays a dual role: precisely timed spikes may not inhibit the firing of in-tune
    head direction cells, while exerting lateral inhibition. Autonomous attractor
    dynamics emerge from a modelled network implementing wiring motifs and timing
    sensitive synaptic interactions in the pyramidal - Martinotti-cell feedback loop.
    This inhibitory microcircuit is therefore tuned to refine and maintain head direction
    information in the presubiculum.'
article_number: '16032'
article_processing_charge: No
author:
- first_name: Jean
  full_name: Simonnet, Jean
  last_name: Simonnet
- first_name: Mérie
  full_name: Nassar, Mérie
  last_name: Nassar
- first_name: Federico
  full_name: Stella, Federico
  id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
  last_name: Stella
  orcid: 0000-0001-9439-3148
- first_name: Ivan
  full_name: Cohen, Ivan
  last_name: Cohen
- first_name: Bertrand
  full_name: Mathon, Bertrand
  last_name: Mathon
- first_name: Charlotte
  full_name: Boccara, Charlotte
  id: 3FC06552-F248-11E8-B48F-1D18A9856A87
  last_name: Boccara
  orcid: 0000-0001-7237-5109
- first_name: Richard
  full_name: Miles, Richard
  last_name: Miles
- first_name: Desdemona
  full_name: Fricker, Desdemona
  last_name: Fricker
citation:
  ama: Simonnet J, Nassar M, Stella F, et al. Activity dependent feedback inhibition
    may maintain head direction signals in mouse presubiculum. <i>Nature Communications</i>.
    2017;8. doi:<a href="https://doi.org/10.1038/ncomms16032">10.1038/ncomms16032</a>
  apa: Simonnet, J., Nassar, M., Stella, F., Cohen, I., Mathon, B., Boccara, C. N.,
    … Fricker, D. (2017). Activity dependent feedback inhibition may maintain head
    direction signals in mouse presubiculum. <i>Nature Communications</i>. Nature
    Publishing Group. <a href="https://doi.org/10.1038/ncomms16032">https://doi.org/10.1038/ncomms16032</a>
  chicago: Simonnet, Jean, Mérie Nassar, Federico Stella, Ivan Cohen, Bertrand Mathon,
    Charlotte N. Boccara, Richard Miles, and Desdemona Fricker. “Activity Dependent
    Feedback Inhibition May Maintain Head Direction Signals in Mouse Presubiculum.”
    <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href="https://doi.org/10.1038/ncomms16032">https://doi.org/10.1038/ncomms16032</a>.
  ieee: J. Simonnet <i>et al.</i>, “Activity dependent feedback inhibition may maintain
    head direction signals in mouse presubiculum,” <i>Nature Communications</i>, vol.
    8. Nature Publishing Group, 2017.
  ista: Simonnet J, Nassar M, Stella F, Cohen I, Mathon B, Boccara CN, Miles R, Fricker
    D. 2017. Activity dependent feedback inhibition may maintain head direction signals
    in mouse presubiculum. Nature Communications. 8, 16032.
  mla: Simonnet, Jean, et al. “Activity Dependent Feedback Inhibition May Maintain
    Head Direction Signals in Mouse Presubiculum.” <i>Nature Communications</i>, vol.
    8, 16032, Nature Publishing Group, 2017, doi:<a href="https://doi.org/10.1038/ncomms16032">10.1038/ncomms16032</a>.
  short: J. Simonnet, M. Nassar, F. Stella, I. Cohen, B. Mathon, C.N. Boccara, R.
    Miles, D. Fricker, Nature Communications 8 (2017).
date_created: 2018-12-11T11:46:54Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2025-09-18T09:48:43Z
day: '01'
ddc:
- '571'
department:
- _id: JoCs
doi: 10.1038/ncomms16032
external_id:
  isi:
  - '000405901100001'
file:
- access_level: open_access
  checksum: 76d8a2b72a58e56adb410ec37dfa7eee
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:31Z
  date_updated: 2020-07-14T12:46:36Z
  file_id: '5083'
  file_name: IST-2018-937-v1+1_2017_Stella_Activity_dependent.pdf
  file_size: 2948357
  relation: main_file
file_date_updated: 2020-07-14T12:46:36Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Nature Publishing Group
publist_id: '7305'
pubrep_id: '937'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Activity dependent feedback inhibition may maintain head direction signals
  in mouse presubiculum
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 8
year: '2017'
...