---
_id: '532'
abstract:
- lang: eng
  text: Ethylene is a gaseous phytohormone that plays vital roles in plant growth
    and development. Previous studies uncovered EIN2 as an essential signal transducer
    linking ethylene perception on ER to transcriptional regulation in the nucleus
    through a “cleave and shuttle” model. In this study, we report another mechanism
    of EIN2-mediated ethylene signaling, whereby EIN2 imposes the translational repression
    of EBF1 and EBF2 mRNA. We find that the EBF1/2 3′ UTRs mediate EIN2-directed translational
    repression and identify multiple poly-uridylates (PolyU) motifs as functional
    cis elements of 3′ UTRs. Furthermore, we demonstrate that ethylene induces EIN2
    to associate with 3′ UTRs and target EBF1/2 mRNA to cytoplasmic processing-body
    (P-body) through interacting with multiple P-body factors, including EIN5 and
    PABs. Our study illustrates translational regulation as a key step in ethylene
    signaling and presents mRNA 3′ UTR functioning as a “signal transducer” to sense
    and relay cellular signaling in plants.
article_processing_charge: No
author:
- first_name: Wenyang
  full_name: Li, Wenyang
  last_name: Li
- first_name: Mengdi
  full_name: Ma, Mengdi
  last_name: Ma
- first_name: Ying
  full_name: Feng, Ying
  last_name: Feng
- first_name: Hongjiang
  full_name: Li, Hongjiang
  id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
  last_name: Li
  orcid: 0000-0001-5039-9660
- first_name: Yichuan
  full_name: Wang, Yichuan
  last_name: Wang
- first_name: Yutong
  full_name: Ma, Yutong
  last_name: Ma
- first_name: Mingzhe
  full_name: Li, Mingzhe
  last_name: Li
- first_name: Fengying
  full_name: An, Fengying
  last_name: An
- first_name: Hongwei
  full_name: Guo, Hongwei
  last_name: Guo
citation:
  ama: Li W, Ma M, Feng Y, et al. EIN2-directed translational regulation of ethylene
    signaling in arabidopsis. <i>Cell</i>. 2015;163(3):670-683. doi:<a href="https://doi.org/10.1016/j.cell.2015.09.037">10.1016/j.cell.2015.09.037</a>
  apa: Li, W., Ma, M., Feng, Y., Li, H., Wang, Y., Ma, Y., … Guo, H. (2015). EIN2-directed
    translational regulation of ethylene signaling in arabidopsis. <i>Cell</i>. Cell
    Press. <a href="https://doi.org/10.1016/j.cell.2015.09.037">https://doi.org/10.1016/j.cell.2015.09.037</a>
  chicago: Li, Wenyang, Mengdi Ma, Ying Feng, Hongjiang Li, Yichuan Wang, Yutong Ma,
    Mingzhe Li, Fengying An, and Hongwei Guo. “EIN2-Directed Translational Regulation
    of Ethylene Signaling in Arabidopsis.” <i>Cell</i>. Cell Press, 2015. <a href="https://doi.org/10.1016/j.cell.2015.09.037">https://doi.org/10.1016/j.cell.2015.09.037</a>.
  ieee: W. Li <i>et al.</i>, “EIN2-directed translational regulation of ethylene signaling
    in arabidopsis,” <i>Cell</i>, vol. 163, no. 3. Cell Press, pp. 670–683, 2015.
  ista: Li W, Ma M, Feng Y, Li H, Wang Y, Ma Y, Li M, An F, Guo H. 2015. EIN2-directed
    translational regulation of ethylene signaling in arabidopsis. Cell. 163(3), 670–683.
  mla: Li, Wenyang, et al. “EIN2-Directed Translational Regulation of Ethylene Signaling
    in Arabidopsis.” <i>Cell</i>, vol. 163, no. 3, Cell Press, 2015, pp. 670–83, doi:<a
    href="https://doi.org/10.1016/j.cell.2015.09.037">10.1016/j.cell.2015.09.037</a>.
  short: W. Li, M. Ma, Y. Feng, H. Li, Y. Wang, Y. Ma, M. Li, F. An, H. Guo, Cell
    163 (2015) 670–683.
date_created: 2018-12-11T11:47:00Z
date_published: 2015-10-22T00:00:00Z
date_updated: 2025-09-23T08:40:43Z
day: '22'
department:
- _id: JiFr
doi: 10.1016/j.cell.2015.09.037
external_id:
  isi:
  - '000364828900020'
fulldoi: https://doi.org/10.1016/j.cell.2015.09.037
intvolume: '       163'
isi: 1
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 670 - 683
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '7285'
quality_controlled: '1'
scopus_import: '1'
status: public
title: EIN2-directed translational regulation of ethylene signaling in arabidopsis
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 163
year: '2015'
...