---
OA_type: free access
_id: '54'
abstract:
- lang: eng
  text: During epithelial tissue development, repair, and homeostasis, adherens junctions
    (AJs) ensure intercellular adhesion and tissue integrity while allowing for cell
    and tissue dynamics. Mechanical forces play critical roles in AJs’ composition
    and dynamics. Recent findings highlight that beyond a well-established role in
    reinforcing cell-cell adhesion, AJ mechanosensitivity promotes junctional remodeling
    and polarization, thereby regulating critical processes such as cell intercalation,
    division, and collective migration. Here, we provide an integrated view of mechanosensing
    mechanisms that regulate cell-cell contact composition, geometry, and integrity
    under tension and highlight pivotal roles for mechanosensitive AJ remodeling in
    preserving epithelial integrity and sustaining tissue dynamics.
acknowledgement: Research in the Bellaïche laboratory is supported by the European
  Research Council (ERC Advanced, TiMoprh, 340784), the Fondation ARC pour la Recherche
  sur le Cancer (SL220130607097), the Agence Nationale de la Recherche (ANR lLabex
  DEEP; 11-LBX-0044, ANR-10-IDEX-0001-02), the Centre National de la Recherche Scientifique,
  the Institut National de la Santé et de la Recherche Médicale, and Institut Curie
  and PSL Research University funding or grants.
article_processing_charge: No
article_type: review
author:
- first_name: Diana C
  full_name: Nunes Pinheiro, Diana C
  id: 2E839F16-F248-11E8-B48F-1D18A9856A87
  last_name: Nunes Pinheiro
  orcid: 0000-0003-4333-7503
- first_name: Yohanns
  full_name: Bellaïche, Yohanns
  last_name: Bellaïche
citation:
  ama: Nunes Pinheiro DC, Bellaïche Y. Mechanical force-driven adherents junction
    remodeling and epithelial dynamics. <i>Developmental Cell</i>. 2018;47(1):3-19.
    doi:<a href="https://doi.org/10.1016/j.devcel.2018.09.014">10.1016/j.devcel.2018.09.014</a>
  apa: Nunes Pinheiro, D. C., &#38; Bellaïche, Y. (2018). Mechanical force-driven
    adherents junction remodeling and epithelial dynamics. <i>Developmental Cell</i>.
    Cell Press. <a href="https://doi.org/10.1016/j.devcel.2018.09.014">https://doi.org/10.1016/j.devcel.2018.09.014</a>
  chicago: Nunes Pinheiro, Diana C, and Yohanns Bellaïche. “Mechanical Force-Driven
    Adherents Junction Remodeling and Epithelial Dynamics.” <i>Developmental Cell</i>.
    Cell Press, 2018. <a href="https://doi.org/10.1016/j.devcel.2018.09.014">https://doi.org/10.1016/j.devcel.2018.09.014</a>.
  ieee: D. C. Nunes Pinheiro and Y. Bellaïche, “Mechanical force-driven adherents
    junction remodeling and epithelial dynamics,” <i>Developmental Cell</i>, vol.
    47, no. 1. Cell Press, pp. 3–19, 2018.
  ista: Nunes Pinheiro DC, Bellaïche Y. 2018. Mechanical force-driven adherents junction
    remodeling and epithelial dynamics. Developmental Cell. 47(1), 3–19.
  mla: Nunes Pinheiro, Diana C., and Yohanns Bellaïche. “Mechanical Force-Driven Adherents
    Junction Remodeling and Epithelial Dynamics.” <i>Developmental Cell</i>, vol.
    47, no. 1, Cell Press, 2018, pp. 3–19, doi:<a href="https://doi.org/10.1016/j.devcel.2018.09.014">10.1016/j.devcel.2018.09.014</a>.
  short: D.C. Nunes Pinheiro, Y. Bellaïche, Developmental Cell 47 (2018) 3–19.
date_created: 2018-12-11T11:44:23Z
date_published: 2018-10-08T00:00:00Z
date_updated: 2026-06-18T18:52:56Z
day: '08'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2018.09.014
external_id:
  isi:
  - '000446579900002'
intvolume: '        47'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.devcel.2018.09.014
month: '10'
oa: 1
oa_version: Published Version
page: 3 - 19
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '8000'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanical force-driven adherents junction remodeling and epithelial dynamics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 47
year: '2018'
...