---
res:
  bibo_abstract:
  - 'While we have good understanding of bacterial metabolism at the population level,
    we know little about the metabolic behavior of individual cells: do single cells
    in clonal populations sometimes specialize on different metabolic pathways? Such
    metabolic specialization could be driven by stochastic gene expression and could
    provide individual cells with growth benefits of specialization. We measured the
    degree of phenotypic specialization in two parallel metabolic pathways, the assimilation
    of glucose and arabinose. We grew Escherichia coli in chemostats, and used isotope-labeled
    sugars in combination with nanometer-scale secondary ion mass spectrometry and
    mathematical modeling to quantify sugar assimilation at the single-cell level.
    We found large variation in metabolic activities between single cells, both in
    absolute assimilation and in the degree to which individual cells specialize in
    the assimilation of different sugars. Analysis of transcriptional reporters indicated
    that this variation was at least partially based on cell-to-cell variation in
    gene expression. Metabolic differences between cells in clonal populations could
    potentially reduce metabolic incompatibilities between different pathways, and
    increase the rate at which parallel reactions can be performed.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nela
      foaf_name: Nikolic, Nela
      foaf_surname: Nikolic
      foaf_workInfoHomepage: http://www.librecat.org/personId=42D9CABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9068-6090
  - foaf_Person:
      foaf_givenName: Frank
      foaf_name: Schreiber, Frank
      foaf_surname: Schreiber
  - foaf_Person:
      foaf_givenName: Alma
      foaf_name: Dal Co, Alma
      foaf_surname: Dal Co
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Kiviet, Daniel
      foaf_surname: Kiviet
  - foaf_Person:
      foaf_givenName: Tobias
      foaf_name: Bergmiller, Tobias
      foaf_surname: Bergmiller
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C471CFA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5396-4346
  - foaf_Person:
      foaf_givenName: Sten
      foaf_name: Littmann, Sten
      foaf_surname: Littmann
  - foaf_Person:
      foaf_givenName: Marcel
      foaf_name: Kuypers, Marcel
      foaf_surname: Kuypers
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Ackermann, Martin
      foaf_surname: Ackermann
  bibo_doi: 10.1371/journal.pgen.1007122
  bibo_issue: '12'
  bibo_volume: 13
  dct_date: 2017^xs_gYear
  dct_identifier:
  - UT:000419103000015
  dct_isPartOf:
  - http://id.crossref.org/issn/1553-7390
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_title: Cell-to-cell variation and specialization in sugar metabolism in clonal
    bacterial populations@
...