---
res:
  bibo_abstract:
  - A comprehensive understanding of the clonal evolution of cancer is critical for
    understanding neoplasia. Genome-wide sequencing data enables evolutionary studies
    at unprecedented depth. However, classical phylogenetic methods often struggle
    with noisy sequencing data of impure DNA samples and fail to detect subclones
    that have different evolutionary trajectories. We have developed a tool, called
    Treeomics, that allows us to reconstruct the phylogeny of a cancer with commonly
    available sequencing technologies. Using Bayesian inference and Integer Linear
    Programming, robust phylogenies consistent with the biological processes underlying
    cancer evolution were obtained for pancreatic, ovarian, and prostate cancers.
    Furthermore, Treeomics correctly identified sequencing artifacts such as those
    resulting from low statistical power; nearly 7% of variants were misclassified
    by conventional statistical methods. These artifacts can skew phylogenies by creating
    illusory tumor heterogeneity among distinct samples. Importantly, we show that
    the evolutionary trees generated with Treeomics are mathematically optimal.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Johannes
      foaf_name: Reiter, Johannes
      foaf_surname: Reiter
      foaf_workInfoHomepage: http://www.librecat.org/personId=4A918E98-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0170-7353
  - foaf_Person:
      foaf_givenName: Alvin
      foaf_name: Makohon-Moore, Alvin
      foaf_surname: Makohon-Moore
  - foaf_Person:
      foaf_givenName: Jeffrey
      foaf_name: Gerold, Jeffrey
      foaf_surname: Gerold
  - foaf_Person:
      foaf_givenName: Ivana
      foaf_name: Bozic, Ivana
      foaf_surname: Bozic
  - foaf_Person:
      foaf_givenName: Krishnendu
      foaf_name: Chatterjee, Krishnendu
      foaf_surname: Chatterjee
      foaf_workInfoHomepage: http://www.librecat.org/personId=2E5DCA20-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4561-241X
  - foaf_Person:
      foaf_givenName: Christine
      foaf_name: Iacobuzio-Donahue, Christine
      foaf_surname: Iacobuzio-Donahue
  - foaf_Person:
      foaf_givenName: Bert
      foaf_name: Vogelstein, Bert
      foaf_surname: Vogelstein
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Nowak, Martin
      foaf_surname: Nowak
  bibo_doi: 10.15479/AT:IST-2015-399-v1-1
  dct_date: 2015^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2664-1690
  dct_language: eng
  dct_publisher: IST Austria@
  dct_title: Reconstructing robust phylogenies of metastatic cancers@
...