--- res: bibo_abstract: - "In continuous populations with local migration, nearby pairs of individuals have on average more similar genotypes\r\nthan geographically well separated pairs. A barrier to gene flow distorts this classical pattern of isolation by distance. Genetic similarity is decreased for sample pairs on different sides of the barrier and increased for pairs on the same side near the barrier. Here, we introduce an inference scheme that utilizes this signal to detect and estimate the strength of a linear barrier to gene flow in two-dimensions. We use a diffusion approximation to model the effects of a barrier on the geographical spread of ancestry backwards in time. This approach allows us to calculate the chance of recent coalescence and probability of identity by descent. We introduce an inference scheme that fits these theoretical results to the geographical covariance structure of bialleleic genetic markers. It can estimate the strength of the barrier as well as several demographic parameters. We investigate the power of our inference scheme to detect barriers by applying it to a wide range of simulated data. We also showcase an example application to a Antirrhinum majus (snapdragon) flower color hybrid zone, where we do not detect any signal of a strong genome wide barrier to gene flow.@eng" bibo_authorlist: - foaf_Person: foaf_givenName: Harald foaf_name: Ringbauer, Harald foaf_surname: Ringbauer foaf_workInfoHomepage: http://www.librecat.org/personId=417FCFF4-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4884-9682 - foaf_Person: foaf_givenName: Alexander foaf_name: Kolesnikov, Alexander foaf_surname: Kolesnikov foaf_workInfoHomepage: http://www.librecat.org/personId=2D157DB6-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: David foaf_name: Field, David foaf_surname: Field - foaf_Person: foaf_givenName: Nicholas H foaf_name: Barton, Nicholas H foaf_surname: Barton foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8548-5240 bibo_doi: 10.1534/genetics.117.300638 bibo_issue: '3' bibo_volume: 208 dct_date: 2018^xs_gYear dct_identifier: - UT:000426219600025 dct_language: eng dct_publisher: Genetics Society of America@ dct_title: Estimating barriers to gene flow from distorted isolation-by-distance patterns@ ...