---
_id: '563'
abstract:
- lang: eng
  text: "In continuous populations with local migration, nearby pairs of individuals
    have on average more similar genotypes\r\nthan geographically well separated pairs.
    A barrier to gene flow distorts this classical pattern of isolation by distance.
    Genetic similarity is decreased for sample pairs on different sides of the barrier
    and increased for pairs on the same side near the barrier. Here, we introduce
    an inference scheme that utilizes this signal to detect and estimate the strength
    of a linear barrier to gene flow in two-dimensions. We use a diffusion approximation
    to model the effects of a barrier on the geographical spread of ancestry backwards
    in time. This approach allows us to calculate the chance of recent coalescence
    and probability of identity by descent. We introduce an inference scheme that
    fits these theoretical results to the geographical covariance structure of bialleleic
    genetic markers. It can estimate the strength of the barrier as well as several
    demographic parameters. We investigate the power of our inference scheme to detect
    barriers by applying it to a wide range of simulated data. We also showcase an
    example application to a Antirrhinum majus (snapdragon) flower color hybrid zone,
    where we do not detect any signal of a strong genome wide barrier to gene flow."
article_processing_charge: No
author:
- first_name: Harald
  full_name: Ringbauer, Harald
  id: 417FCFF4-F248-11E8-B48F-1D18A9856A87
  last_name: Ringbauer
  orcid: 0000-0002-4884-9682
- first_name: Alexander
  full_name: Kolesnikov, Alexander
  id: 2D157DB6-F248-11E8-B48F-1D18A9856A87
  last_name: Kolesnikov
- first_name: David
  full_name: Field, David
  last_name: Field
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Ringbauer H, Kolesnikov A, Field D, Barton NH. Estimating barriers to gene
    flow from distorted isolation-by-distance patterns. <i>Genetics</i>. 2018;208(3):1231-1245.
    doi:<a href="https://doi.org/10.1534/genetics.117.300638">10.1534/genetics.117.300638</a>
  apa: Ringbauer, H., Kolesnikov, A., Field, D., &#38; Barton, N. H. (2018). Estimating
    barriers to gene flow from distorted isolation-by-distance patterns. <i>Genetics</i>.
    Genetics Society of America. <a href="https://doi.org/10.1534/genetics.117.300638">https://doi.org/10.1534/genetics.117.300638</a>
  chicago: Ringbauer, Harald, Alexander Kolesnikov, David Field, and Nicholas H Barton.
    “Estimating Barriers to Gene Flow from Distorted Isolation-by-Distance Patterns.”
    <i>Genetics</i>. Genetics Society of America, 2018. <a href="https://doi.org/10.1534/genetics.117.300638">https://doi.org/10.1534/genetics.117.300638</a>.
  ieee: H. Ringbauer, A. Kolesnikov, D. Field, and N. H. Barton, “Estimating barriers
    to gene flow from distorted isolation-by-distance patterns,” <i>Genetics</i>,
    vol. 208, no. 3. Genetics Society of America, pp. 1231–1245, 2018.
  ista: Ringbauer H, Kolesnikov A, Field D, Barton NH. 2018. Estimating barriers to
    gene flow from distorted isolation-by-distance patterns. Genetics. 208(3), 1231–1245.
  mla: Ringbauer, Harald, et al. “Estimating Barriers to Gene Flow from Distorted
    Isolation-by-Distance Patterns.” <i>Genetics</i>, vol. 208, no. 3, Genetics Society
    of America, 2018, pp. 1231–45, doi:<a href="https://doi.org/10.1534/genetics.117.300638">10.1534/genetics.117.300638</a>.
  short: H. Ringbauer, A. Kolesnikov, D. Field, N.H. Barton, Genetics 208 (2018) 1231–1245.
corr_author: '1'
date_created: 2018-12-11T11:47:12Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2026-04-08T14:06:35Z
day: '01'
department:
- _id: NiBa
- _id: ChLa
doi: 10.1534/genetics.117.300638
external_id:
  isi:
  - '000426219600025'
intvolume: '       208'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/205484v1
month: '03'
oa: 1
oa_version: Preprint
page: 1231-1245
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '7251'
quality_controlled: '1'
related_material:
  record:
  - id: '200'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Estimating barriers to gene flow from distorted isolation-by-distance patterns
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 208
year: '2018'
...