---
res:
  bibo_abstract:
  - Most phenotypes are determined by molecular systems composed of specifically interacting
    molecules. However, unlike for individual components, little is known about the
    distributions of mutational effects of molecular systems as a whole. We ask how
    the distribution of mutational effects of a transcriptional regulatory system
    differs from the distributions of its components, by first independently, and
    then simultaneously, mutating a transcription factor and the associated promoter
    it represses. We find that the system distribution exhibits increased phenotypic
    variation compared to individual component distributions - an effect arising from
    intermolecular epistasis between the transcription factor and its DNA-binding
    site. In large part, this epistasis can be qualitatively attributed to the structure
    of the transcriptional regulatory system and could therefore be a common feature
    in prokaryotes. Counter-intuitively, intermolecular epistasis can alleviate the
    constraints of individual components, thereby increasing phenotypic variation
    that selection could act on and facilitating adaptive evolution. @eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Mato
      foaf_name: Lagator, Mato
      foaf_surname: Lagator
      foaf_workInfoHomepage: http://www.librecat.org/personId=345D25EC-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Srdjan
      foaf_name: Sarikas, Srdjan
      foaf_surname: Sarikas
      foaf_workInfoHomepage: http://www.librecat.org/personId=35F0286E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Hande
      foaf_name: Acar, Hande
      foaf_surname: Acar
      foaf_workInfoHomepage: http://www.librecat.org/personId=2DDF136A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1986-9753
  - foaf_Person:
      foaf_givenName: Jonathan P
      foaf_name: Bollback, Jonathan P
      foaf_surname: Bollback
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C6FA9CC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4624-4612
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  bibo_doi: 10.7554/eLife.28921
  bibo_volume: 6
  dct_date: 2017^xs_gYear
  dct_identifier:
  - UT:000425868200001
  dct_isPartOf:
  - http://id.crossref.org/issn/2050-084X
  dct_language: eng
  dct_publisher: eLife Sciences Publications@
  dct_title: Regulatory network structure determines patterns of intermolecular epistasis@
...