[{"oa_version":"Published Version","file":[{"creator":"system","file_size":8453470,"content_type":"application/pdf","access_level":"open_access","file_name":"IST-2017-918-v1+1_elife-28921-figures-v3.pdf","checksum":"273ab17f33305e4eaafd911ff88e7c5b","date_created":"2018-12-12T10:14:42Z","date_updated":"2020-07-14T12:47:10Z","file_id":"5096","relation":"main_file"},{"access_level":"open_access","file_name":"IST-2017-918-v1+2_elife-28921-v3.pdf","creator":"system","content_type":"application/pdf","file_size":1953221,"file_id":"5097","relation":"main_file","checksum":"b433f90576c7be597cd43367946f8e7f","date_created":"2018-12-12T10:14:43Z","date_updated":"2020-07-14T12:47:10Z"}],"pubrep_id":"918","intvolume":" 6","status":"public","ddc":[],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"570","abstract":[{"lang":"eng"}],"type":"journal_article","date_published":"2017-11-13T00:00:00Z","citation":{"ieee":"M. Lagator, S. Sarikas, H. Acar, J. P. Bollback, and C. C. Guet, “Regulatory network structure determines patterns of intermolecular epistasis,” eLife, vol. 6. eLife Sciences Publications, 2017.","apa":"Lagator, M., Sarikas, S., Acar, H., Bollback, J. P., & Guet, C. C. (2017). Regulatory network structure determines patterns of intermolecular epistasis. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.28921","ista":"Lagator M, Sarikas S, Acar H, Bollback JP, Guet CC. 2017. Regulatory network structure determines patterns of intermolecular epistasis. eLife. 6, e28921.","short":"M. Lagator, S. Sarikas, H. Acar, J.P. Bollback, C.C. Guet, ELife 6 (2017).","mla":"Lagator, Mato, et al. “Regulatory Network Structure Determines Patterns of Intermolecular Epistasis.” ELife, vol. 6, e28921, eLife Sciences Publications, 2017, doi:10.7554/eLife.28921.","chicago":"Lagator, Mato, Srdjan Sarikas, Hande Acar, Jonathan P Bollback, and Calin C Guet. “Regulatory Network Structure Determines Patterns of Intermolecular Epistasis.” ELife. eLife Sciences Publications, 2017. https://doi.org/10.7554/eLife.28921."},"publication":"eLife","uri_base":"https://research-explorer.ista.ac.at","has_accepted_license":"1","day":"13","scopus_import":1,"dc":{"identifier":["https://research-explorer.ista.ac.at/record/570","https://research-explorer.ista.ac.at/download/570/5096","https://research-explorer.ista.ac.at/download/570/5097"],"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"description":["Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how the distribution of mutational effects of a transcriptional regulatory system differs from the distributions of its components, by first independently, and then simultaneously, mutating a transcription factor and the associated promoter it represses. We find that the system distribution exhibits increased phenotypic variation compared to individual component distributions - an effect arising from intermolecular epistasis between the transcription factor and its DNA-binding site. In large part, this epistasis can be qualitatively attributed to the structure of the transcriptional regulatory system and could therefore be a common feature in prokaryotes. Counter-intuitively, intermolecular epistasis can alleviate the constraints of individual components, thereby increasing phenotypic variation that selection could act on and facilitating adaptive evolution. "],"creator":["Lagator, Mato","Sarikas, Srdjan","Acar, Hande","Bollback, Jonathan P","Guet, Calin C"],"source":["Lagator M, Sarikas S, Acar H, Bollback JP, Guet CC. Regulatory network structure determines patterns of intermolecular epistasis. eLife. 2017;6. doi:10.7554/eLife.28921"],"rights":["https://creativecommons.org/licenses/by/4.0/","info:eu-repo/semantics/openAccess"],"title":["Regulatory network structure determines patterns of intermolecular epistasis"],"relation":["info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.28921","info:eu-repo/semantics/altIdentifier/issn/2050084X","info:eu-repo/grantAgreement/EC/FP7/291734","info:eu-repo/grantAgreement/EC/H2020/648440"],"publisher":["eLife Sciences Publications"],"subject":["ddc:576"],"date":["2017"],"language":["eng"]},"volume":6,"date_created":"2018-12-11T11:47:14Z","dini_type":"doc-type:article","date_updated":"2021-01-12T08:03:15Z","author":[{"first_name":"Mato","last_name":"Lagator","id":"345D25EC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Srdjan","last_name":"Sarikas","id":"35F0286E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hande","last_name":"Acar","id":"2DDF136A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1986-9753"},{"last_name":"Bollback","first_name":"Jonathan P","orcid":"0000-0002-4624-4612","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87"},{"id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052","first_name":"Calin C","last_name":"Guet"}],"department":[{"tree":[{"_id":"ResearchGroups"},{"_id":"IST"}],"_id":"CaGu"},{"tree":[{"_id":"ResearchGroups"},{"_id":"IST"}],"_id":"JoBo"},{"tree":[{"_id":"ResearchGroups"},{"_id":"IST"}],"_id":"NiBa"}],"publication_status":"published","creator":{"login":"apreinsp","id":"4435EBFC-F248-11E8-B48F-1D18A9856A87"},"ec_funded":1,"publist_id":"7244","file_date_updated":"2020-07-14T12:47:10Z","article_number":"e28921","language":[{}],"project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"_id":"2578D616-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Selective Barriers to Horizontal Gene Transfer"}],"quality_controlled":"1","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_identifier":{"issn":[]},"month":"11"}]