Migrating platelets are mechano scavengers that collect and bundle bacteria

article Migrating platelets are mechano scavengers that collect and bundle bacteria published yes Florian R Gärtner author 397A88EE-F248-11E8-B48F-1D18A9856A870000-0001-6120-3723 Zerkah Ahmad author Gerhild Rosenberger author Shuxia Fan author Leo Nicolai author Benjamin Busch author Gökce Yavuz author Manja Luckner author Hellen Ishikawa Ankerhold author Roman Hennel author Alexandre Benechet author Michael Lorenz author Sue Chandraratne author Irene Schubert author Sebastian Helmer author Bianca Striednig author Konstantin Stark author Marek Janko author Ralph Böttcher author Admar Verschoor author Catherine Leon author Christian Gachet author Thomas Gudermann author Michael Mederos Y Schnitzler author Zachary Pincus author Matteo Iannacone author Rainer Haas author Gerhard Wanner author Kirsten Lauber author Michael K Sixt author 41E9FBEA-F248-11E8-B48F-1D18A9856A870000-0002-6620-9179 Steffen Massberg author MiSi department Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells project Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune responses. Despite these versatile tasks in mammalian biology, their skills on a cellular level are deemed limited, mainly consisting in rolling, adhesion, and aggregate formation. Here, we identify an unappreciated asset of platelets and show that adherent platelets use adhesion receptors to mechanically probe the adhesive substrate in their local microenvironment. When actomyosin-dependent traction forces overcome substrate resistance, platelets migrate and pile up the adhesive substrate together with any bound particulate material. They use this ability to act as cellular scavengers, scanning the vascular surface for potential invaders and collecting deposited bacteria. Microbe collection by migrating platelets boosts the activity of professional phagocytes, exacerbating inflammatory tissue injury in sepsis. This assigns platelets a central role in innate immune responses and identifies them as potential targets to dampen inflammatory tissue damage in clinical scenarios of severe systemic infection. In addition to their role in thrombosis and hemostasis, platelets can also migrate to sites of infection to help trap bacteria and clear the vascular surface. Cell Press2017 eng Cell Press 0092-8674 00041736270001810.1016/j.cell.2017.11.001 17161368 - 1382 Gärtner, F. R., Ahmad, Z., Rosenberger, G., Fan, S., Nicolai, L., Busch, B., … Massberg, S. (2017). Migrating platelets are mechano scavengers that collect and bundle bacteria. Cell Press. Cell Press. <a href="https://doi.org/10.1016/j.cell.2017.11.001">https://doi.org/10.1016/j.cell.2017.11.001</a> Gärtner, Florian R, Zerkah Ahmad, Gerhild Rosenberger, Shuxia Fan, Leo Nicolai, Benjamin Busch, Gökce Yavuz, et al. “Migrating Platelets Are Mechano Scavengers That Collect and Bundle Bacteria.” Cell Press. Cell Press, 2017. <a href="https://doi.org/10.1016/j.cell.2017.11.001">https://doi.org/10.1016/j.cell.2017.11.001</a>. Gärtner FR, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher R, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt MK, Massberg S. 2017. Migrating platelets are mechano scavengers that collect and bundle bacteria. Cell Press. 171(6), 1368–1382. F.R. Gärtner, Z. Ahmad, G. Rosenberger, S. Fan, L. Nicolai, B. Busch, G. Yavuz, M. Luckner, H. Ishikawa Ankerhold, R. Hennel, A. Benechet, M. Lorenz, S. Chandraratne, I. Schubert, S. Helmer, B. Striednig, K. Stark, M. Janko, R. Böttcher, A. Verschoor, C. Leon, C. Gachet, T. Gudermann, M. Mederos Y Schnitzler, Z. Pincus, M. Iannacone, R. Haas, G. Wanner, K. Lauber, M.K. Sixt, S. Massberg, Cell Press 171 (2017) 1368–1382. Gärtner, Florian R., et al. “Migrating Platelets Are Mechano Scavengers That Collect and Bundle Bacteria.” Cell Press, vol. 171, no. 6, Cell Press, 2017, pp. 1368–82, doi:<a href="https://doi.org/10.1016/j.cell.2017.11.001">10.1016/j.cell.2017.11.001</a>. Gärtner FR, Ahmad Z, Rosenberger G, et al. Migrating platelets are mechano scavengers that collect and bundle bacteria. Cell Press. 2017;171(6):1368-1382. doi:<a href="https://doi.org/10.1016/j.cell.2017.11.001">10.1016/j.cell.2017.11.001</a> F. R. Gärtner et al., “Migrating platelets are mechano scavengers that collect and bundle bacteria,” Cell Press, vol. 171, no. 6. Cell Press, pp. 1368–1382, 2017. 5712018-12-11T11:47:15Z2025-09-11T07:39:45Z