--- res: bibo_abstract: - 'Because of the intrinsic randomness of the evolutionary process, a mutant with a fitness advantage has some chance to be selected but no certainty. Any experiment that searches for advantageous mutants will lose many of them due to random drift. It is therefore of great interest to find population structures that improve the odds of advantageous mutants. Such structures are called amplifiers of natural selection: they increase the probability that advantageous mutants are selected. Arbitrarily strong amplifiers guarantee the selection of advantageous mutants, even for very small fitness advantage. Despite intensive research over the past decade, arbitrarily strong amplifiers have remained rare. Here we show how to construct a large variety of them. Our amplifiers are so simple that they could be useful in biotechnology, when optimizing biological molecules, or as a diagnostic tool, when searching for faster dividing cells or viruses. They could also occur in natural population structures.@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Andreas foaf_name: Pavlogiannis, Andreas foaf_surname: Pavlogiannis foaf_workInfoHomepage: http://www.librecat.org/personId=49704004-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8943-0722 - foaf_Person: foaf_givenName: Josef foaf_name: Tkadlec, Josef foaf_surname: Tkadlec foaf_workInfoHomepage: http://www.librecat.org/personId=3F24CCC8-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-1097-9684 - foaf_Person: foaf_givenName: Krishnendu foaf_name: Chatterjee, Krishnendu foaf_surname: Chatterjee foaf_workInfoHomepage: http://www.librecat.org/personId=2E5DCA20-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4561-241X - foaf_Person: foaf_givenName: Martin A. foaf_name: Nowak, Martin A. foaf_surname: Nowak bibo_doi: 10.1038/s42003-018-0078-7 bibo_issue: '1' bibo_volume: 1 dct_date: 2018^xs_gYear dct_identifier: - UT:000461126500071 dct_isPartOf: - http://id.crossref.org/issn/2399-3642 dct_language: eng dct_publisher: Springer Nature@ dct_title: Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory@ ...