--- res: bibo_abstract: - Hippocampus is needed for both spatial working and reference memories. Here, using a radial eight-arm maze, we examined how the combined demand on these memories influenced CA1 place cell assemblies while reference memories were partially updated. This was contrasted with control tasks requiring only working memory or the update of reference memory. Reference memory update led to the reward-directed place field shifts at newly rewarded arms and to the gradual strengthening of firing in passes between newly rewarded arms but not between those passes that included a familiar-rewarded arm. At the maze center, transient network synchronization periods preferentially replayed trajectories of the next chosen arm in reference memory tasks but the previously visited arm in the working memory task. Hence, reference memory demand was uniquely associated with a gradual, goal novelty-related reorganization of place cell assemblies and with trajectory replay that reflected the animal's decision of which arm to visit next.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Haibing foaf_name: Xu, Haibing foaf_surname: Xu foaf_workInfoHomepage: http://www.librecat.org/personId=310349D0-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Peter foaf_name: Baracskay, Peter foaf_surname: Baracskay foaf_workInfoHomepage: http://www.librecat.org/personId=361CC00E-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Joseph foaf_name: O'Neill, Joseph foaf_surname: O'Neill foaf_workInfoHomepage: http://www.librecat.org/personId=426376DC-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Jozsef L foaf_name: Csicsvari, Jozsef L foaf_surname: Csicsvari foaf_workInfoHomepage: http://www.librecat.org/personId=3FA14672-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-5193-4036 bibo_doi: 10.1016/j.neuron.2018.11.015 bibo_issue: '1' bibo_volume: 101 dct_date: 2019^xs_gYear dct_identifier: - UT:000454791500014 dct_isPartOf: - http://id.crossref.org/issn/10974199 dct_language: eng dct_publisher: Elsevier@ dct_title: Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze@ ...