{"department":[{"_id":"JoCs"}],"oa":1,"abstract":[{"lang":"eng","text":"With the advent of optogenetics, it became possible to change the activity of a targeted population of neurons in a temporally controlled manner. To combine the advantages of 60-channel in vivo tetrode recording and laser-based optogenetics, we have developed a closed-loop recording system that allows for the actual electrophysiological signal to be used as a trigger for the laser light mediating the optogenetic intervention. We have optimized the weight, size, and shape of the corresponding implant to make it compatible with the size, force, and movements of a behaving mouse, and we have shown that the system can efficiently block sharp wave ripple (SWR) events using those events themselves as a trigger. To demonstrate the full potential of the optogenetic recording system we present a pilot study addressing the contribution of SWR events to learning in a complex behavioral task."}],"ec_funded":1,"oa_version":"Published Version","date_published":"2018-07-27T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","file":[{"access_level":"open_access","file_id":"5921","relation":"main_file","file_name":"2018_ENeuro_Guerrero.pdf","content_type":"application/pdf","date_updated":"2020-07-14T12:47:13Z","file_size":3746884,"date_created":"2019-02-05T12:48:36Z","checksum":"f4915d45fc7ad4648b7b7a13fdecca01","creator":"dernst"}],"article_number":"e0087","publisher":"Society of Neuroscience","issue":"4","day":"27","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"},{"name":"Interneuron plasticity during spatial learning","grant_number":"I2072-B27","_id":"257D4372-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"intvolume":"         5","file_date_updated":"2020-07-14T12:47:13Z","date_created":"2019-02-03T22:59:16Z","language":[{"iso":"eng"}],"article_processing_charge":"No","title":"Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"6849"}]},"status":"public","isi":1,"publication_status":"published","ddc":["570"],"volume":5,"scopus_import":"1","publication":"eNeuro","month":"07","citation":{"ista":"Rangel Guerrero DK, Donnett JG, Csicsvari JL, Kovács K. 2018. Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning. eNeuro. 5(4), e0087.","mla":"Rangel Guerrero, Dámaris K., et al. “Tetrode Recording from the Hippocampus of Behaving Mice Coupled with Four-Point-Irradiation Closed-Loop Optogenetics: A Technique to Study the Contribution of Hippocampal SWR Events to Learning.” <i>ENeuro</i>, vol. 5, no. 4, e0087, Society of Neuroscience, 2018, doi:<a href=\"https://doi.org/10.1523/ENEURO.0087-18.2018\">10.1523/ENEURO.0087-18.2018</a>.","ama":"Rangel Guerrero DK, Donnett JG, Csicsvari JL, Kovács K. Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning. <i>eNeuro</i>. 2018;5(4). doi:<a href=\"https://doi.org/10.1523/ENEURO.0087-18.2018\">10.1523/ENEURO.0087-18.2018</a>","chicago":"Rangel Guerrero, Dámaris K, James G. Donnett, Jozsef L Csicsvari, and Krisztián Kovács. “Tetrode Recording from the Hippocampus of Behaving Mice Coupled with Four-Point-Irradiation Closed-Loop Optogenetics: A Technique to Study the Contribution of Hippocampal SWR Events to Learning.” <i>ENeuro</i>. Society of Neuroscience, 2018. <a href=\"https://doi.org/10.1523/ENEURO.0087-18.2018\">https://doi.org/10.1523/ENEURO.0087-18.2018</a>.","apa":"Rangel Guerrero, D. K., Donnett, J. G., Csicsvari, J. L., &#38; Kovács, K. (2018). Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning. <i>ENeuro</i>. Society of Neuroscience. <a href=\"https://doi.org/10.1523/ENEURO.0087-18.2018\">https://doi.org/10.1523/ENEURO.0087-18.2018</a>","ieee":"D. K. Rangel Guerrero, J. G. Donnett, J. L. Csicsvari, and K. Kovács, “Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning,” <i>eNeuro</i>, vol. 5, no. 4. Society of Neuroscience, 2018.","short":"D.K. Rangel Guerrero, J.G. Donnett, J.L. Csicsvari, K. Kovács, ENeuro 5 (2018)."},"year":"2018","_id":"5914","doi":"10.1523/ENEURO.0087-18.2018","quality_controlled":"1","external_id":{"isi":["000443994700007"]},"author":[{"full_name":"Rangel Guerrero, Dámaris K","last_name":"Rangel Guerrero","orcid":"0000-0002-8602-4374","id":"4871BCE6-F248-11E8-B48F-1D18A9856A87","first_name":"Dámaris K"},{"full_name":"Donnett, James G.","last_name":"Donnett","first_name":"James G."},{"first_name":"Jozsef L","orcid":"0000-0002-5193-4036","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L"},{"full_name":"Kovács, Krisztián","id":"2AB5821E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6251-1007","last_name":"Kovács","first_name":"Krisztián"}],"date_updated":"2024-04-18T22:30:48Z","has_accepted_license":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"}