{"date_created":"2018-12-11T11:47:23Z","publication":"Nature Reviews Molecular Cell Biology","volume":16,"page":"129 - 143","date_updated":"2021-01-12T08:05:16Z","month":"03","title":"Structural basis of transcription initiation by RNA polymerase II","_id":"594","date_published":"2015-03-26T00:00:00Z","author":[{"last_name":"Sainsbury","full_name":"Sainsbury, Sarah","first_name":"Sarah"},{"last_name":"Bernecky","full_name":"Bernecky, Carrie A","first_name":"Carrie A","id":"2CB9DFE2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0893-7036"},{"last_name":"Cramer","full_name":"Cramer, Patrick","first_name":"Patrick"}],"status":"public","year":"2015","type":"journal_article","day":"26","oa_version":"None","publication_status":"published","citation":{"chicago":"Sainsbury, Sarah, Carrie Bernecky, and Patrick Cramer. “Structural Basis of Transcription Initiation by RNA Polymerase II.” <i>Nature Reviews Molecular Cell Biology</i>. Nature Publishing Group, 2015. <a href=\"https://doi.org/10.1038/nrm3952\">https://doi.org/10.1038/nrm3952</a>.","ama":"Sainsbury S, Bernecky C, Cramer P. Structural basis of transcription initiation by RNA polymerase II. <i>Nature Reviews Molecular Cell Biology</i>. 2015;16(3):129-143. doi:<a href=\"https://doi.org/10.1038/nrm3952\">10.1038/nrm3952</a>","ieee":"S. Sainsbury, C. Bernecky, and P. Cramer, “Structural basis of transcription initiation by RNA polymerase II,” <i>Nature Reviews Molecular Cell Biology</i>, vol. 16, no. 3. Nature Publishing Group, pp. 129–143, 2015.","short":"S. Sainsbury, C. Bernecky, P. Cramer, Nature Reviews Molecular Cell Biology 16 (2015) 129–143.","apa":"Sainsbury, S., Bernecky, C., &#38; Cramer, P. (2015). Structural basis of transcription initiation by RNA polymerase II. <i>Nature Reviews Molecular Cell Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nrm3952\">https://doi.org/10.1038/nrm3952</a>","ista":"Sainsbury S, Bernecky C, Cramer P. 2015. Structural basis of transcription initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology. 16(3), 129–143.","mla":"Sainsbury, Sarah, et al. “Structural Basis of Transcription Initiation by RNA Polymerase II.” <i>Nature Reviews Molecular Cell Biology</i>, vol. 16, no. 3, Nature Publishing Group, 2015, pp. 129–43, doi:<a href=\"https://doi.org/10.1038/nrm3952\">10.1038/nrm3952</a>."},"doi":"10.1038/nrm3952","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        16","publist_id":"7206","abstract":[{"text":"Transcription of eukaryotic protein-coding genes commences with the assembly of a conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general transcription factors, at promoter DNA. After two decades of research, the structural basis of transcription initiation is emerging. Crystal structures of many components of the initiation complex have been resolved, and structural information on Pol II complexes with general transcription factors has recently been obtained. Although mechanistic details await elucidation, available data outline how Pol II cooperates with the general transcription factors to bind to and open promoter DNA, and how Pol II directs RNA synthesis and escapes from the promoter.","lang":"eng"}],"publisher":"Nature Publishing Group","language":[{"iso":"eng"}],"issue":"3","extern":"1","article_processing_charge":"No"}