---
res:
  bibo_abstract:
  - Pleiotropy is the well-established idea that a single mutation affects multiple
    phenotypes. If a mutation has opposite effects on fitness when expressed in different
    contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce
    the efficacy of selection by limiting the fixation of beneficial mutations through
    adaptation, and the removal of deleterious mutations through purifying selection.
    Although this has been widely discussed, in particular in the context of a putative
    “gender load,” it has yet to be systematically quantified. In this work, we empirically
    estimate to which extent different pleiotropic regimes impede the efficacy of
    selection in Drosophila melanogaster. We use whole-genome polymorphism data from
    a single African population and divergence data from D. simulans to estimate the
    fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction
    of selection (DoS). After controlling for confounding covariates, we find that
    the different pleiotropic regimes have a relatively small, but significant, effect
    on selection efficacy. Specifically, our results suggest that pleiotropic sexual
    antagonism may restrict the efficacy of selection, but that this conflict can
    be resolved by limiting the expression of genes to the sex where they are beneficial.
    Intermediate levels of pleiotropy across tissues and life stages can also lead
    to maladaptation in D. melanogaster, due to inefficient purifying selection combined
    with low frequency of mutations that confer a selective advantage. Thus, our study
    highlights the need to consider the efficacy of selection in the context of antagonistic
    pleiotropy, and of genetic conflict in general.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Christelle
      foaf_name: Fraisse, Christelle
      foaf_surname: Fraisse
      foaf_workInfoHomepage: http://www.librecat.org/personId=32DF5794-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8441-5075
  - foaf_Person:
      foaf_givenName: Gemma
      foaf_name: Puixeu Sala, Gemma
      foaf_surname: Puixeu Sala
      foaf_workInfoHomepage: http://www.librecat.org/personId=33AB266C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8330-1754
  - foaf_Person:
      foaf_givenName: Beatriz
      foaf_name: Vicoso, Beatriz
      foaf_surname: Vicoso
      foaf_workInfoHomepage: http://www.librecat.org/personId=49E1C5C6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4579-8306
  bibo_doi: 10.1093/molbev/msy246
  bibo_issue: '3'
  bibo_volume: 36
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000462585100006
  dct_isPartOf:
  - http://id.crossref.org/issn/0737-4038
  - http://id.crossref.org/issn/1537-1719
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: Pleiotropy modulates the efficacy of selection in drosophila melanogaster@
  fabio_hasPubmedId: '30590559'
...