---
_id: '6089'
abstract:
- lang: eng
  text: Pleiotropy is the well-established idea that a single mutation affects multiple
    phenotypes. If a mutation has opposite effects on fitness when expressed in different
    contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce
    the efficacy of selection by limiting the fixation of beneficial mutations through
    adaptation, and the removal of deleterious mutations through purifying selection.
    Although this has been widely discussed, in particular in the context of a putative
    “gender load,” it has yet to be systematically quantified. In this work, we empirically
    estimate to which extent different pleiotropic regimes impede the efficacy of
    selection in Drosophila melanogaster. We use whole-genome polymorphism data from
    a single African population and divergence data from D. simulans to estimate the
    fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction
    of selection (DoS). After controlling for confounding covariates, we find that
    the different pleiotropic regimes have a relatively small, but significant, effect
    on selection efficacy. Specifically, our results suggest that pleiotropic sexual
    antagonism may restrict the efficacy of selection, but that this conflict can
    be resolved by limiting the expression of genes to the sex where they are beneficial.
    Intermediate levels of pleiotropy across tissues and life stages can also lead
    to maladaptation in D. melanogaster, due to inefficient purifying selection combined
    with low frequency of mutations that confer a selective advantage. Thus, our study
    highlights the need to consider the efficacy of selection in the context of antagonistic
    pleiotropy, and of genetic conflict in general.
article_processing_charge: No
author:
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: Gemma
  full_name: Puixeu Sala, Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
  orcid: 0000-0001-8330-1754
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Fraisse C, Puixeu Sala G, Vicoso B. Pleiotropy modulates the efficacy of selection
    in drosophila melanogaster. <i>Molecular biology and evolution</i>. 2019;36(3):500-515.
    doi:<a href="https://doi.org/10.1093/molbev/msy246">10.1093/molbev/msy246</a>
  apa: Fraisse, C., Puixeu Sala, G., &#38; Vicoso, B. (2019). Pleiotropy modulates
    the efficacy of selection in drosophila melanogaster. <i>Molecular Biology and
    Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/molbev/msy246">https://doi.org/10.1093/molbev/msy246</a>
  chicago: Fraisse, Christelle, Gemma Puixeu Sala, and Beatriz Vicoso. “Pleiotropy
    Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular
    Biology and Evolution</i>. Oxford University Press, 2019. <a href="https://doi.org/10.1093/molbev/msy246">https://doi.org/10.1093/molbev/msy246</a>.
  ieee: C. Fraisse, G. Puixeu Sala, and B. Vicoso, “Pleiotropy modulates the efficacy
    of selection in drosophila melanogaster,” <i>Molecular biology and evolution</i>,
    vol. 36, no. 3. Oxford University Press, pp. 500–515, 2019.
  ista: Fraisse C, Puixeu Sala G, Vicoso B. 2019. Pleiotropy modulates the efficacy
    of selection in drosophila melanogaster. Molecular biology and evolution. 36(3),
    500–515.
  mla: Fraisse, Christelle, et al. “Pleiotropy Modulates the Efficacy of Selection
    in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>, vol. 36,
    no. 3, Oxford University Press, 2019, pp. 500–15, doi:<a href="https://doi.org/10.1093/molbev/msy246">10.1093/molbev/msy246</a>.
  short: C. Fraisse, G. Puixeu Sala, B. Vicoso, Molecular Biology and Evolution 36
    (2019) 500–515.
date_created: 2019-03-10T22:59:19Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2025-04-15T08:18:38Z
day: '01'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1093/molbev/msy246
external_id:
  isi:
  - '000462585100006'
  pmid:
  - '30590559'
intvolume: '        36'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30590559
month: '03'
oa: 1
oa_version: Submitted Version
page: 500-515
pmid: 1
project:
- _id: 250ED89C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28842-B22
  name: Sex chromosome evolution under male- and female- heterogamety
publication: Molecular biology and evolution
publication_identifier:
  eissn:
  - 1537-1719
  issn:
  - 0737-4038
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  record:
  - id: '5757'
    relation: popular_science
    status: public
scopus_import: '1'
status: public
title: Pleiotropy modulates the efficacy of selection in drosophila melanogaster
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 36
year: '2019'
...