[{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","status":"public","_id":"6091","file_date_updated":"2020-07-14T12:47:19Z","department":[{"_id":"SiHi","tree":[{"_id":"ResearchGroups"},{"_id":"IST"}]}],"date_updated":"2023-08-24T14:50:50Z","ddc":[],"creator":{"login":"apreinsp","id":"4435EBFC-F248-11E8-B48F-1D18A9856A87"},"scopus_import":"1","intvolume":" 8","month":"02","abstract":[{"lang":"eng"}],"oa_version":"Published Version","pmid":1,"volume":8,"publication_status":"published","language":[{}],"file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_id":"6098","checksum":"7b0800d003f14cd06b1802dea0c52941","file_size":7260753,"date_updated":"2020-07-14T12:47:19Z","creator":"dernst","file_name":"2019_eLife_Henderson.pdf","date_created":"2019-03-11T16:15:37Z"}],"article_number":"e41563","article_processing_charge":"No","external_id":{"isi":[],"pmid":[]},"author":[{"last_name":"Henderson","first_name":"Nathan T."},{"last_name":"Le Marchand","first_name":"Sylvain J."},{"last_name":"Hruska","first_name":"Martin"},{"orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Liqun","last_name":"Luo"},{"last_name":"Dalva","first_name":"Matthew B."}],"citation":{"ista":"Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. 2019. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. eLife. 8, e41563.","chicago":"Henderson, Nathan T., Sylvain J. Le Marchand, Martin Hruska, Simon Hippenmeyer, Liqun Luo, and Matthew B. Dalva. “Ephrin-B3 Controls Excitatory Synapse Density through Cell-Cell Competition for EphBs.” ELife. eLife Sciences Publications, 2019. https://doi.org/10.7554/eLife.41563.","short":"N.T. Henderson, S.J. Le Marchand, M. Hruska, S. Hippenmeyer, L. Luo, M.B. Dalva, ELife 8 (2019).","ieee":"N. T. Henderson, S. J. Le Marchand, M. Hruska, S. Hippenmeyer, L. Luo, and M. B. Dalva, “Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs,” eLife, vol. 8. eLife Sciences Publications, 2019.","apa":"Henderson, N. T., Le Marchand, S. J., Hruska, M., Hippenmeyer, S., Luo, L., & Dalva, M. B. (2019). Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.41563","mla":"Henderson, Nathan T., et al. “Ephrin-B3 Controls Excitatory Synapse Density through Cell-Cell Competition for EphBs.” ELife, vol. 8, e41563, eLife Sciences Publications, 2019, doi:10.7554/eLife.41563."},"dini_type":"doc-type:article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"quality_controlled":"1","uri_base":"https://research-explorer.ista.ac.at","date_created":"2019-03-10T22:59:20Z","date_published":"2019-02-21T00:00:00Z","isi":1,"has_accepted_license":"1","dc":{"subject":["ddc:570"],"creator":["Henderson, Nathan T.","Le Marchand, Sylvain J.","Hruska, Martin","Hippenmeyer, Simon","Luo, Liqun","Dalva, Matthew B."],"language":["eng"],"rights":["https://creativecommons.org/licenses/by/4.0/","info:eu-repo/semantics/openAccess"],"title":["Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs"],"description":["Cortical networks are characterized by sparse connectivity, with synapses found at only a subset of axo-dendritic contacts. Yet within these networks, neurons can exhibit high connection probabilities, suggesting that cell-intrinsic factors, not proximity, determine connectivity. Here, we identify ephrin-B3 (eB3) as a factor that determines synapse density by mediating a cell-cell competition that requires ephrin-B-EphB signaling. In a microisland culture system designed to isolate cell-cell competition, we find that eB3 determines winning and losing neurons in a contest for synapses. In a Mosaic Analysis with Double Markers (MADM) genetic mouse model system in vivo the relative levels of eB3 control spine density in layer 5 and 6 neurons. MADM cortical neurons in vitro reveal that eB3 controls synapse density independently of action potential-driven activity. Our findings illustrate a new class of competitive mechanism mediated by trans-synaptic organizing proteins which control the number of synapses neurons receive relative to neighboring neurons."],"identifier":["https://research-explorer.ista.ac.at/record/6091","https://research-explorer.ista.ac.at/download/6091/6098"],"relation":["info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.41563","info:eu-repo/semantics/altIdentifier/wos/000459380600001","info:eu-repo/semantics/altIdentifier/pmid/30789343"],"source":["Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. eLife. 2019;8. doi:10.7554/eLife.41563"],"publisher":["eLife Sciences Publications"],"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"date":["2019"]},"publication":"eLife","day":"21"}]