---
res:
  bibo_abstract:
  - Different interoceptive systems must be integrated to ensure that multiple homeostatic
    insults evoke appropriate behavioral and physiological responses. Little is known
    about how this is achieved. Using C. elegans, we dissect cross-modulation between
    systems that monitor temperature, O2 and CO2. CO2 is less aversive to animals
    acclimated to 15°C than those grown at 22°C. This difference requires the AFD
    neurons, which respond to both temperature and CO2 changes. CO2 evokes distinct
    AFD Ca2+ responses in animals acclimated at 15°C or 22°C. Mutants defective in
    synaptic transmission can reprogram AFD CO2 responses according to temperature
    experience, suggesting reprogramming occurs cell autonomously. AFD is exquisitely
    sensitive to CO2. Surprisingly, gradients of 0.01% CO2/second evoke very different
    Ca2+ responses from gradients of 0.04% CO2/second. Ambient O2 provides further
    contextual modulation of CO2 avoidance. At 21% O2 tonic signalling from the O2-sensing
    neuron URX inhibits CO2 avoidance. This inhibition can be graded according to
    O2 levels. In a natural wild isolate, a switch from 21% to 19% O2 is sufficient
    to convert CO2 from a neutral to an aversive cue. This sharp tuning is conferred
    partly by the neuroglobin GLB-5. The modulatory effects of O2 on CO2 avoidance
    involve the RIA interneurons, which are post-synaptic to URX and exhibit CO2-evoked
    Ca2+ responses. Ambient O2 and acclimation temperature act combinatorially to
    modulate CO2 responsiveness. Our work highlights the integrated architecture of
    homeostatic responses in C. elegans.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Eiji
      foaf_name: Kodama-Namba, Eiji
      foaf_surname: Kodama-Namba
  - foaf_Person:
      foaf_givenName: Lorenz A.
      foaf_name: Fenk, Lorenz A.
      foaf_surname: Fenk
  - foaf_Person:
      foaf_givenName: Andrew J.
      foaf_name: Bretscher, Andrew J.
      foaf_surname: Bretscher
  - foaf_Person:
      foaf_givenName: Einav
      foaf_name: Gross, Einav
      foaf_surname: Gross
  - foaf_Person:
      foaf_givenName: K. Emanuel
      foaf_name: Busch, K. Emanuel
      foaf_surname: Busch
  - foaf_Person:
      foaf_givenName: Mario
      foaf_name: de Bono, Mario
      foaf_surname: de Bono
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8347-0443
  bibo_doi: 10.1371/journal.pgen.1004011
  bibo_issue: '12'
  bibo_volume: 9
  dct_date: 2013^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1553-7404
  dct_language: eng
  dct_publisher: Public Library of Science (PLoS)@
  dct_title: Cross-modulation of homeostatic responses to temperature, oxygen and
    carbon dioxide in C. elegans@
  fabio_hasPubmedId: '24385919'
...