---
_id: '6128'
abstract:
- lang: eng
  text: Different interoceptive systems must be integrated to ensure that multiple
    homeostatic insults evoke appropriate behavioral and physiological responses.
    Little is known about how this is achieved. Using C. elegans, we dissect cross-modulation
    between systems that monitor temperature, O2 and CO2. CO2 is less aversive to
    animals acclimated to 15°C than those grown at 22°C. This difference requires
    the AFD neurons, which respond to both temperature and CO2 changes. CO2 evokes
    distinct AFD Ca2+ responses in animals acclimated at 15°C or 22°C. Mutants defective
    in synaptic transmission can reprogram AFD CO2 responses according to temperature
    experience, suggesting reprogramming occurs cell autonomously. AFD is exquisitely
    sensitive to CO2. Surprisingly, gradients of 0.01% CO2/second evoke very different
    Ca2+ responses from gradients of 0.04% CO2/second. Ambient O2 provides further
    contextual modulation of CO2 avoidance. At 21% O2 tonic signalling from the O2-sensing
    neuron URX inhibits CO2 avoidance. This inhibition can be graded according to
    O2 levels. In a natural wild isolate, a switch from 21% to 19% O2 is sufficient
    to convert CO2 from a neutral to an aversive cue. This sharp tuning is conferred
    partly by the neuroglobin GLB-5. The modulatory effects of O2 on CO2 avoidance
    involve the RIA interneurons, which are post-synaptic to URX and exhibit CO2-evoked
    Ca2+ responses. Ambient O2 and acclimation temperature act combinatorially to
    modulate CO2 responsiveness. Our work highlights the integrated architecture of
    homeostatic responses in C. elegans.
article_number: e1004011
author:
- first_name: Eiji
  full_name: Kodama-Namba, Eiji
  last_name: Kodama-Namba
- first_name: Lorenz A.
  full_name: Fenk, Lorenz A.
  last_name: Fenk
- first_name: Andrew J.
  full_name: Bretscher, Andrew J.
  last_name: Bretscher
- first_name: Einav
  full_name: Gross, Einav
  last_name: Gross
- first_name: K. Emanuel
  full_name: Busch, K. Emanuel
  last_name: Busch
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
citation:
  ama: Kodama-Namba E, Fenk LA, Bretscher AJ, Gross E, Busch KE, de Bono M. Cross-modulation
    of homeostatic responses to temperature, oxygen and carbon dioxide in C. elegans.
    <i>PLoS Genetics</i>. 2013;9(12). doi:<a href="https://doi.org/10.1371/journal.pgen.1004011">10.1371/journal.pgen.1004011</a>
  apa: Kodama-Namba, E., Fenk, L. A., Bretscher, A. J., Gross, E., Busch, K. E., &#38;
    de Bono, M. (2013). Cross-modulation of homeostatic responses to temperature,
    oxygen and carbon dioxide in C. elegans. <i>PLoS Genetics</i>. Public Library
    of Science (PLoS). <a href="https://doi.org/10.1371/journal.pgen.1004011">https://doi.org/10.1371/journal.pgen.1004011</a>
  chicago: Kodama-Namba, Eiji, Lorenz A. Fenk, Andrew J. Bretscher, Einav Gross, K.
    Emanuel Busch, and Mario de Bono. “Cross-Modulation of Homeostatic Responses to
    Temperature, Oxygen and Carbon Dioxide in C. Elegans.” <i>PLoS Genetics</i>. Public
    Library of Science (PLoS), 2013. <a href="https://doi.org/10.1371/journal.pgen.1004011">https://doi.org/10.1371/journal.pgen.1004011</a>.
  ieee: E. Kodama-Namba, L. A. Fenk, A. J. Bretscher, E. Gross, K. E. Busch, and M.
    de Bono, “Cross-modulation of homeostatic responses to temperature, oxygen and
    carbon dioxide in C. elegans,” <i>PLoS Genetics</i>, vol. 9, no. 12. Public Library
    of Science (PLoS), 2013.
  ista: Kodama-Namba E, Fenk LA, Bretscher AJ, Gross E, Busch KE, de Bono M. 2013.
    Cross-modulation of homeostatic responses to temperature, oxygen and carbon dioxide
    in C. elegans. PLoS Genetics. 9(12), e1004011.
  mla: Kodama-Namba, Eiji, et al. “Cross-Modulation of Homeostatic Responses to Temperature,
    Oxygen and Carbon Dioxide in C. Elegans.” <i>PLoS Genetics</i>, vol. 9, no. 12,
    e1004011, Public Library of Science (PLoS), 2013, doi:<a href="https://doi.org/10.1371/journal.pgen.1004011">10.1371/journal.pgen.1004011</a>.
  short: E. Kodama-Namba, L.A. Fenk, A.J. Bretscher, E. Gross, K.E. Busch, M. de Bono,
    PLoS Genetics 9 (2013).
date_created: 2019-03-19T14:58:51Z
date_published: 2013-12-19T00:00:00Z
date_updated: 2021-01-12T08:06:15Z
day: '19'
ddc:
- '570'
doi: 10.1371/journal.pgen.1004011
extern: '1'
external_id:
  pmid:
  - '24385919'
file:
- access_level: open_access
  checksum: 299b6321be79931c7c17c5db6e69c711
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-03-19T15:14:51Z
  date_updated: 2020-07-14T12:47:20Z
  file_id: '6129'
  file_name: 2013_PLOS_Kodama-Namba.PDF
  file_size: 4499039
  relation: main_file
file_date_updated: 2020-07-14T12:47:20Z
has_accepted_license: '1'
intvolume: '         9'
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLoS Genetics
publication_identifier:
  issn:
  - 1553-7404
publication_status: published
publisher: Public Library of Science (PLoS)
quality_controlled: '1'
status: public
title: Cross-modulation of homeostatic responses to temperature, oxygen and carbon
  dioxide in C. elegans
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2013'
...