---
res:
  bibo_abstract:
  - 'Bacteria in groups vary individually, and interact with other bacteria and the
    environment to produce population-level patterns of gene expression. Investigating
    such behavior in detail requires measuring and controlling populations at the
    single-cell level alongside precisely specified interactions and environmental
    characteristics. Here we present an automated, programmable platform that combines
    image-based gene expression and growth measurements with on-line optogenetic expression
    control for hundreds of individual Escherichia coli cells over days, in a dynamically
    adjustable environment. This integrated platform broadly enables experiments that
    bridge individual and population behaviors. We demonstrate: (i) population structuring
    by independent closed-loop control of gene expression in many individual cells,
    (ii) cell-cell variation control during antibiotic perturbation, (iii) hybrid
    bio-digital circuits in single cells, and freely specifiable digital communication
    between individual bacteria. These examples showcase the potential for real-time
    integration of theoretical models with measurement and control of many individual
    cells to investigate and engineer microbial population behavior.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Remy P
      foaf_name: Chait, Remy P
      foaf_surname: Chait
      foaf_workInfoHomepage: http://www.librecat.org/personId=3464AE84-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-0876-3187
  - foaf_Person:
      foaf_givenName: Jakob
      foaf_name: Ruess, Jakob
      foaf_surname: Ruess
      foaf_workInfoHomepage: http://www.librecat.org/personId=4A245D00-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1615-3282
  - foaf_Person:
      foaf_givenName: Tobias
      foaf_name: Bergmiller, Tobias
      foaf_surname: Bergmiller
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C471CFA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5396-4346
  - foaf_Person:
      foaf_givenName: Gasper
      foaf_name: Tkacik, Gasper
      foaf_surname: Tkacik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  bibo_doi: 10.1038/s41467-017-01683-1
  bibo_issue: '1'
  bibo_volume: 8
  dct_date: 2017^xs_gYear
  dct_identifier:
  - UT:000415323000008
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Shaping bacterial population behavior through computer interfaced control
    of individual cells@
...