---
_id: '6156'
abstract:
- lang: eng
  text: 'Social and solitary feeding in natural Caenorhabditis elegans isolates are
    associated with two alleles of the orphan G-protein-coupled receptor (GPCR) NPR-1:
    social feeders contain NPR-1 215F, whereas solitary feeders contain NPR-1 215V.
    Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the flp-18
    and flp-21 genes as NPR-1 ligands and show that these peptides can differentially
    activate the NPR-1 215F and NPR-1 215V receptors. Multicopy overexpression of
    flp-21 transformed wild social animals into solitary feeders. Conversely, a flp-21
    deletion partially phenocopied the npr-1(null) phenotype, which is consistent
    with NPR-1 activation by FLP-21 in vivo but also implicates other ligands for
    NPR-1. Phylogenetic studies indicate that the dominant npr-1 215V allele likely
    arose from an ancestral npr-1 215F gene in C. elegans. Our data suggest a model
    in which solitary feeding evolved in an ancestral social strain of C. elegans
    by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and
    FLP-21 ligands.'
author:
- first_name: Candida
  full_name: Rogers, Candida
  last_name: Rogers
- first_name: Vincenzina
  full_name: Reale, Vincenzina
  last_name: Reale
- first_name: Kyuhyung
  full_name: Kim, Kyuhyung
  last_name: Kim
- first_name: Heather
  full_name: Chatwin, Heather
  last_name: Chatwin
- first_name: Chris
  full_name: Li, Chris
  last_name: Li
- first_name: Peter
  full_name: Evans, Peter
  last_name: Evans
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
citation:
  ama: Rogers C, Reale V, Kim K, et al. Inhibition of Caenorhabditis elegans social
    feeding by FMRFamide-related peptide activation of NPR-1. <i>Nature Neuroscience</i>.
    2003;6(11):1178-1185. doi:<a href="https://doi.org/10.1038/nn1140">10.1038/nn1140</a>
  apa: Rogers, C., Reale, V., Kim, K., Chatwin, H., Li, C., Evans, P., &#38; de Bono,
    M. (2003). Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related
    peptide activation of NPR-1. <i>Nature Neuroscience</i>. Springer Nature. <a href="https://doi.org/10.1038/nn1140">https://doi.org/10.1038/nn1140</a>
  chicago: Rogers, Candida, Vincenzina Reale, Kyuhyung Kim, Heather Chatwin, Chris
    Li, Peter Evans, and Mario de Bono. “Inhibition of Caenorhabditis Elegans Social
    Feeding by FMRFamide-Related Peptide Activation of NPR-1.” <i>Nature Neuroscience</i>.
    Springer Nature, 2003. <a href="https://doi.org/10.1038/nn1140">https://doi.org/10.1038/nn1140</a>.
  ieee: C. Rogers <i>et al.</i>, “Inhibition of Caenorhabditis elegans social feeding
    by FMRFamide-related peptide activation of NPR-1,” <i>Nature Neuroscience</i>,
    vol. 6, no. 11. Springer Nature, pp. 1178–1185, 2003.
  ista: Rogers C, Reale V, Kim K, Chatwin H, Li C, Evans P, de Bono M. 2003. Inhibition
    of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation
    of NPR-1. Nature Neuroscience. 6(11), 1178–1185.
  mla: Rogers, Candida, et al. “Inhibition of Caenorhabditis Elegans Social Feeding
    by FMRFamide-Related Peptide Activation of NPR-1.” <i>Nature Neuroscience</i>,
    vol. 6, no. 11, Springer Nature, 2003, pp. 1178–85, doi:<a href="https://doi.org/10.1038/nn1140">10.1038/nn1140</a>.
  short: C. Rogers, V. Reale, K. Kim, H. Chatwin, C. Li, P. Evans, M. de Bono, Nature
    Neuroscience 6 (2003) 1178–1185.
date_created: 2019-03-21T09:47:53Z
date_published: 2003-10-12T00:00:00Z
date_updated: 2021-01-12T08:06:25Z
day: '12'
doi: 10.1038/nn1140
extern: '1'
external_id:
  pmid:
  - '14555955'
fulldoi: https://doi.org/10.1038/nn1140
intvolume: '         6'
issue: '11'
language:
- iso: eng
month: '10'
oa_version: None
page: 1178-1185
pmid: 1
publication: Nature Neuroscience
publication_identifier:
  issn:
  - 1097-6256
  - 1546-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide
  activation of NPR-1
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2003'
...