@article{6160,
  abstract     = {Natural isolates of C. elegans exhibit either solitary or social feeding behavior. Solitary foragers move slowly on a bacterial lawn and disperse across it, while social foragers move rapidly on bacteria and aggregate together. A loss-of-function mutation in the npr-1 gene, which encodes a predicted G protein–coupled receptor similar to neuropeptide Y receptors, causes a solitary strain to take on social behavior. Two isoforms of NPR-1 that differ at a single residue occur in the wild. One isoform, NPR-1 215F, is found exclusively in social strains, while the other isoform, NPR-1 215V, is found exclusively in solitary strains. An NPR-1 215V transgene can induce solitary feeding behavior in a wild social strain. Thus, isoforms of a putative neuropeptide receptor generate natural variation in C. elegans feeding behavior.},
  author       = {de Bono, Mario and Bargmann, Cornelia I},
  issn         = {0092-8674},
  journal      = {Cell},
  number       = {5},
  pages        = {679--689},
  publisher    = {Elsevier},
  title        = {{Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans}},
  doi          = {10.1016/s0092-8674(00)81609-8},
  volume       = {94},
  year         = {1998},
}