Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans de Bono, Mario ; https://orcid.org/0000-0001-8347-0443 Bargmann, Cornelia I Natural isolates of C. elegans exhibit either solitary or social feeding behavior. Solitary foragers move slowly on a bacterial lawn and disperse across it, while social foragers move rapidly on bacteria and aggregate together. A loss-of-function mutation in the npr-1 gene, which encodes a predicted G protein–coupled receptor similar to neuropeptide Y receptors, causes a solitary strain to take on social behavior. Two isoforms of NPR-1 that differ at a single residue occur in the wild. One isoform, NPR-1 215F, is found exclusively in social strains, while the other isoform, NPR-1 215V, is found exclusively in solitary strains. An NPR-1 215V transgene can induce solitary feeding behavior in a wild social strain. Thus, isoforms of a putative neuropeptide receptor generate natural variation in C. elegans feeding behavior. Elsevier 1998 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/6160 de Bono M, Bargmann CI. Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. <i>Cell</i>. 1998;94(5):679-689. doi:<a href="https://doi.org/10.1016/s0092-8674(00)81609-8">10.1016/s0092-8674(00)81609-8</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1016/s0092-8674(00)81609-8 info:eu-repo/semantics/altIdentifier/issn/0092-8674 info:eu-repo/semantics/altIdentifier/pmid/9741632 info:eu-repo/semantics/closedAccess