article published yes Mario de Bono author 4E3FF80E-F248-11E8-B48F-1D18A9856A870000-0001-8347-0443 Cornelia I Bargmann author Natural isolates of C. elegans exhibit either solitary or social feeding behavior. Solitary foragers move slowly on a bacterial lawn and disperse across it, while social foragers move rapidly on bacteria and aggregate together. A loss-of-function mutation in the npr-1 gene, which encodes a predicted G protein–coupled receptor similar to neuropeptide Y receptors, causes a solitary strain to take on social behavior. Two isoforms of NPR-1 that differ at a single residue occur in the wild. One isoform, NPR-1 215F, is found exclusively in social strains, while the other isoform, NPR-1 215V, is found exclusively in solitary strains. An NPR-1 215V transgene can induce solitary feeding behavior in a wild social strain. Thus, isoforms of a putative neuropeptide receptor generate natural variation in C. elegans feeding behavior. Elsevier1998 eng 0092-8674 974163210.1016/s0092-8674(00)81609-8 945679-689 yes M. de Bono and C. I. Bargmann, “Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans,” <i>Cell</i>, vol. 94, no. 5. Elsevier, pp. 679–689, 1998. de Bono, Mario, and Cornelia I. Bargmann. “Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C. Elegans.” <i>Cell</i>, vol. 94, no. 5, Elsevier, 1998, pp. 679–89, doi:<a href="https://doi.org/10.1016/s0092-8674(00)81609-8">10.1016/s0092-8674(00)81609-8</a>. de Bono M, Bargmann CI. Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. <i>Cell</i>. 1998;94(5):679-689. doi:<a href="https://doi.org/10.1016/s0092-8674(00)81609-8">10.1016/s0092-8674(00)81609-8</a> M. de Bono, C.I. Bargmann, Cell 94 (1998) 679–689. de Bono, M., &#38; Bargmann, C. I. (1998). Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. <i>Cell</i>. Elsevier. <a href="https://doi.org/10.1016/s0092-8674(00)81609-8">https://doi.org/10.1016/s0092-8674(00)81609-8</a> de Bono M, Bargmann CI. 1998. Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. Cell. 94(5), 679–689. Bono, Mario de, and Cornelia I Bargmann. “Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C. Elegans.” <i>Cell</i>. Elsevier, 1998. <a href="https://doi.org/10.1016/s0092-8674(00)81609-8">https://doi.org/10.1016/s0092-8674(00)81609-8</a>. 61602019-03-21T10:32:06Z2021-01-12T08:06:28Z