---
_id: '6160'
abstract:
- lang: eng
  text: Natural isolates of C. elegans exhibit either solitary or social feeding behavior.
    Solitary foragers move slowly on a bacterial lawn and disperse across it, while
    social foragers move rapidly on bacteria and aggregate together. A loss-of-function
    mutation in the npr-1 gene, which encodes a predicted G protein–coupled receptor
    similar to neuropeptide Y receptors, causes a solitary strain to take on social
    behavior. Two isoforms of NPR-1 that differ at a single residue occur in the wild.
    One isoform, NPR-1 215F, is found exclusively in social strains, while the other
    isoform, NPR-1 215V, is found exclusively in solitary strains. An NPR-1 215V transgene
    can induce solitary feeding behavior in a wild social strain. Thus, isoforms of
    a putative neuropeptide receptor generate natural variation in C. elegans feeding
    behavior.
author:
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Cornelia I
  full_name: Bargmann, Cornelia I
  last_name: Bargmann
citation:
  ama: de Bono M, Bargmann CI. Natural variation in a neuropeptide Y receptor homolog
    modifies social behavior and food response in C. elegans. <i>Cell</i>. 1998;94(5):679-689.
    doi:<a href="https://doi.org/10.1016/s0092-8674(00)81609-8">10.1016/s0092-8674(00)81609-8</a>
  apa: de Bono, M., &#38; Bargmann, C. I. (1998). Natural variation in a neuropeptide
    Y receptor homolog modifies social behavior and food response in C. elegans. <i>Cell</i>.
    Elsevier. <a href="https://doi.org/10.1016/s0092-8674(00)81609-8">https://doi.org/10.1016/s0092-8674(00)81609-8</a>
  chicago: Bono, Mario de, and Cornelia I Bargmann. “Natural Variation in a Neuropeptide
    Y Receptor Homolog Modifies Social Behavior and Food Response in C. Elegans.”
    <i>Cell</i>. Elsevier, 1998. <a href="https://doi.org/10.1016/s0092-8674(00)81609-8">https://doi.org/10.1016/s0092-8674(00)81609-8</a>.
  ieee: M. de Bono and C. I. Bargmann, “Natural variation in a neuropeptide Y receptor
    homolog modifies social behavior and food response in C. elegans,” <i>Cell</i>,
    vol. 94, no. 5. Elsevier, pp. 679–689, 1998.
  ista: de Bono M, Bargmann CI. 1998. Natural variation in a neuropeptide Y receptor
    homolog modifies social behavior and food response in C. elegans. Cell. 94(5),
    679–689.
  mla: de Bono, Mario, and Cornelia I. Bargmann. “Natural Variation in a Neuropeptide
    Y Receptor Homolog Modifies Social Behavior and Food Response in C. Elegans.”
    <i>Cell</i>, vol. 94, no. 5, Elsevier, 1998, pp. 679–89, doi:<a href="https://doi.org/10.1016/s0092-8674(00)81609-8">10.1016/s0092-8674(00)81609-8</a>.
  short: M. de Bono, C.I. Bargmann, Cell 94 (1998) 679–689.
date_created: 2019-03-21T10:32:06Z
date_published: 1998-09-04T00:00:00Z
date_updated: 2021-01-12T08:06:28Z
day: '04'
doi: 10.1016/s0092-8674(00)81609-8
extern: '1'
external_id:
  pmid:
  - '9741632'
intvolume: '        94'
issue: '5'
language:
- iso: eng
month: '09'
oa_version: None
page: 679-689
pmid: 1
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Natural variation in a neuropeptide Y receptor homolog modifies social behavior
  and food response in C. elegans
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 94
year: '1998'
...