---
_id: '617'
abstract:
- lang: eng
  text: Insects are exposed to a variety of potential pathogens in their environment,
    many of which can severely impact fitness and health. Consequently, hosts have
    evolved resistance and tolerance strategies to suppress or cope with infections.
    Hosts utilizing resistance improve fitness by clearing or reducing pathogen loads,
    and hosts utilizing tolerance reduce harmful fitness effects per pathogen load.
    To understand variation in, and selective pressures on, resistance and tolerance,
    we asked to what degree they are shaped by host genetic background, whether plasticity
    in these responses depends upon dietary environment, and whether there are interactions
    between these two factors. Females from ten wild-type Drosophila melanogaster
    genotypes were kept on high- or low-protein (yeast) diets and infected with one
    of two opportunistic bacterial pathogens, Lactococcus lactis or Pseudomonas entomophila.
    We measured host resistance as the inverse of bacterial load in the early infection
    phase. The relationship (slope) between fly fecundity and individual-level bacteria
    load provided our fecundity tolerance measure. Genotype and dietary yeast determined
    host fecundity and strongly affected survival after infection with pathogenic
    P. entomophila. There was considerable genetic variation in host resistance, a
    commonly found phenomenon resulting from for example varying resistance costs
    or frequency-dependent selection. Despite this variation and the reproductive
    cost of higher P. entomophila loads, fecundity tolerance did not vary across genotypes.
    The absence of genetic variation in tolerance may suggest that at this early infection
    stage, fecundity tolerance is fixed or that any evolved tolerance mechanisms are
    not expressed under these infection conditions.
acknowledgement: 'We would like to thank Susann Wicke for performing the genome-wide
  SNP/indel analyses, as well as Veronica Alves, Kevin Ferro, Momir Futo, Barbara
  Hasert, Dafne Maximo, Nora Schulz, Marlene Sroka, and Barth Wieczorek for technical
  help. We thank Brian Lazzaro for the L. lactis strain and Bruno Lemaitre for the
  Pseudomonas entomophila strain. We would like to thank two anonymous reviewers for
  their helpful comments. We are grateful to the Deutsche Forschungsgemeinschaft (DFG)
  priority programme 1399 ‘Host parasite coevolution’ for funding this project (AR
  872/1-1). '
article_processing_charge: No
article_type: original
author:
- first_name: Megan
  full_name: Kutzer, Megan
  id: 29D0B332-F248-11E8-B48F-1D18A9856A87
  last_name: Kutzer
  orcid: 0000-0002-8696-6978
- first_name: Joachim
  full_name: Kurtz, Joachim
  last_name: Kurtz
- first_name: Sophie
  full_name: Armitage, Sophie
  last_name: Armitage
citation:
  ama: Kutzer M, Kurtz J, Armitage S. Genotype and diet affect resistance, survival,
    and fecundity but not fecundity tolerance. <i>Journal of Evolutionary Biology</i>.
    2018;31(1):159-171. doi:<a href="https://doi.org/10.1111/jeb.13211">10.1111/jeb.13211</a>
  apa: Kutzer, M., Kurtz, J., &#38; Armitage, S. (2018). Genotype and diet affect
    resistance, survival, and fecundity but not fecundity tolerance. <i>Journal of
    Evolutionary Biology</i>. Wiley. <a href="https://doi.org/10.1111/jeb.13211">https://doi.org/10.1111/jeb.13211</a>
  chicago: Kutzer, Megan, Joachim Kurtz, and Sophie Armitage. “Genotype and Diet Affect
    Resistance, Survival, and Fecundity but Not Fecundity Tolerance.” <i>Journal of
    Evolutionary Biology</i>. Wiley, 2018. <a href="https://doi.org/10.1111/jeb.13211">https://doi.org/10.1111/jeb.13211</a>.
  ieee: M. Kutzer, J. Kurtz, and S. Armitage, “Genotype and diet affect resistance,
    survival, and fecundity but not fecundity tolerance,” <i>Journal of Evolutionary
    Biology</i>, vol. 31, no. 1. Wiley, pp. 159–171, 2018.
  ista: Kutzer M, Kurtz J, Armitage S. 2018. Genotype and diet affect resistance,
    survival, and fecundity but not fecundity tolerance. Journal of Evolutionary Biology.
    31(1), 159–171.
  mla: Kutzer, Megan, et al. “Genotype and Diet Affect Resistance, Survival, and Fecundity
    but Not Fecundity Tolerance.” <i>Journal of Evolutionary Biology</i>, vol. 31,
    no. 1, Wiley, 2018, pp. 159–71, doi:<a href="https://doi.org/10.1111/jeb.13211">10.1111/jeb.13211</a>.
  short: M. Kutzer, J. Kurtz, S. Armitage, Journal of Evolutionary Biology 31 (2018)
    159–171.
date_created: 2018-12-11T11:47:31Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2026-06-18T19:00:18Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1111/jeb.13211
external_id:
  isi:
  - '000419307000014'
  pmid:
  - '29150962'
intvolume: '        31'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1111/jeb.13211
month: '01'
oa: 1
oa_version: Published Version
page: 159  - 171
pmid: 1
publication: Journal of Evolutionary Biology
publication_identifier:
  eissn:
  - 1420-9101
  issn:
  - 1010-061X
publication_status: published
publisher: Wiley
publist_id: '7187'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genotype and diet affect resistance, survival, and fecundity but not fecundity
  tolerance
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2018'
...