---
_id: '6191'
abstract:
- lang: eng
  text: The formation of self-organized patterns is key to the morphogenesis of multicellular
    organisms, although a comprehensive theory of biological pattern formation is
    still lacking. Here, we propose a minimal model combining tissue mechanics with
    morphogen turnover and transport to explore routes to patterning. Our active description
    couples morphogen reaction and diffusion, which impact cell differentiation and
    tissue mechanics, to a two-phase poroelastic rheology, where one tissue phase
    consists of a poroelastic cell network and the other one of a permeating extracellular
    fluid, which provides a feedback by actively transporting morphogens. While this
    model encompasses previous theories approximating tissues to inert monophasic
    media, such as Turing’s reaction–diffusion model, it overcomes some of their key
    limitations permitting pattern formation via any two-species biochemical kinetics
    due to mechanically induced cross-diffusion flows. Moreover, we describe a qualitatively
    different advection-driven Keller–Segel instability which allows for the formation
    of patterns with a single morphogen and whose fundamental mode pattern robustly
    scales with tissue size. We discuss the potential relevance of these findings
    for tissue morphogenesis.
article_processing_charge: No
author:
- first_name: Pierre
  full_name: Recho, Pierre
  last_name: Recho
- first_name: Adrien
  full_name: Hallou, Adrien
  last_name: Hallou
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
citation:
  ama: Recho P, Hallou A, Hannezo EB. Theory of mechanochemical patterning in biphasic
    biological tissues. <i>Proceedings of the National Academy of Sciences of the
    United States of America</i>. 2019;116(12):5344-5349. doi:<a href="https://doi.org/10.1073/pnas.1813255116">10.1073/pnas.1813255116</a>
  apa: Recho, P., Hallou, A., &#38; Hannezo, E. B. (2019). Theory of mechanochemical
    patterning in biphasic biological tissues. <i>Proceedings of the National Academy
    of Sciences of the United States of America</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.1813255116">https://doi.org/10.1073/pnas.1813255116</a>
  chicago: Recho, Pierre, Adrien Hallou, and Edouard B Hannezo. “Theory of Mechanochemical
    Patterning in Biphasic Biological Tissues.” <i>Proceedings of the National Academy
    of Sciences of the United States of America</i>. National Academy of Sciences,
    2019. <a href="https://doi.org/10.1073/pnas.1813255116">https://doi.org/10.1073/pnas.1813255116</a>.
  ieee: P. Recho, A. Hallou, and E. B. Hannezo, “Theory of mechanochemical patterning
    in biphasic biological tissues,” <i>Proceedings of the National Academy of Sciences
    of the United States of America</i>, vol. 116, no. 12. National Academy of Sciences,
    pp. 5344–5349, 2019.
  ista: Recho P, Hallou A, Hannezo EB. 2019. Theory of mechanochemical patterning
    in biphasic biological tissues. Proceedings of the National Academy of Sciences
    of the United States of America. 116(12), 5344–5349.
  mla: Recho, Pierre, et al. “Theory of Mechanochemical Patterning in Biphasic Biological
    Tissues.” <i>Proceedings of the National Academy of Sciences of the United States
    of America</i>, vol. 116, no. 12, National Academy of Sciences, 2019, pp. 5344–49,
    doi:<a href="https://doi.org/10.1073/pnas.1813255116">10.1073/pnas.1813255116</a>.
  short: P. Recho, A. Hallou, E.B. Hannezo, Proceedings of the National Academy of
    Sciences of the United States of America 116 (2019) 5344–5349.
corr_author: '1'
date_created: 2019-03-31T21:59:13Z
date_published: 2019-03-19T00:00:00Z
date_updated: 2025-07-10T11:53:14Z
day: '19'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1073/pnas.1813255116
external_id:
  isi:
  - '000461679000027'
  pmid:
  - '30819884'
file:
- access_level: open_access
  checksum: 8b67eee0ea8e5db61583e4d485215258
  content_type: application/pdf
  creator: dernst
  date_created: 2019-04-03T14:10:30Z
  date_updated: 2020-07-14T12:47:23Z
  file_id: '6193'
  file_name: 2019_PNAS_Recho.pdf
  file_size: 3456045
  relation: main_file
file_date_updated: 2020-07-14T12:47:23Z
has_accepted_license: '1'
intvolume: '       116'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: 5344-5349
pmid: 1
project:
- _id: 268294B6-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P31639
  name: Active mechano-chemical description of the cell cytoskeleton
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
  link:
  - relation: supplementary_material
    url: www.pnas.org/lookup/suppl/doi:10.1073/pnas.1813255116/-/DCSupplemental
scopus_import: '1'
status: public
title: Theory of mechanochemical patterning in biphasic biological tissues
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 116
year: '2019'
...