article published yes Robert J Beattie author 2E26DF60-F248-11E8-B48F-1D18A9856A870000-0002-8483-8753 Simon Hippenmeyer author 37B36620-F248-11E8-B48F-1D18A9856A870000-0003-2279-1061 SiHi department Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal Level project Molecular Mechanisms of Cerebral Cortex Development project The mammalian cerebral cortex is responsible for higher cognitive functions such as perception, consciousness, and acquiring and processing information. The neocortex is organized into six distinct laminae, each composed of a rich diversity of cell types which assemble into highly complex cortical circuits. Radial glia progenitors (RGPs) are responsible for producing all neocortical neurons and certain glia lineages. Here, we discuss recent discoveries emerging from clonal lineage analysis at the single RGP cell level that provide us with an inaugural quantitative framework of RGP lineage progression. We further discuss the importance of the relative contribution of intrinsic gene functions and non-cell-autonomous or community effects in regulating RGP proliferation behavior and lineage progression. https://research-explorer.ista.ac.at/download/621/5211/IST-2018-928-v1+1_Beattie_et_al-2017-FEBS_Letters.pdf application/pdfno https://creativecommons.org/licenses/by-nc/4.0/ Wiley-Blackwell2017 eng 0014-5793 29121403 00041882570000410.1002/1873-3468.12906 591243993 - 4008 Beattie, Robert J, and Simon Hippenmeyer. “Mechanisms of Radial Glia Progenitor Cell Lineage Progression.” <i>FEBS Letters</i>. Wiley-Blackwell, 2017. <a href="https://doi.org/10.1002/1873-3468.12906">https://doi.org/10.1002/1873-3468.12906</a>. Beattie, Robert J., and Simon Hippenmeyer. “Mechanisms of Radial Glia Progenitor Cell Lineage Progression.” <i>FEBS Letters</i>, vol. 591, no. 24, Wiley-Blackwell, 2017, pp. 3993–4008, doi:<a href="https://doi.org/10.1002/1873-3468.12906">10.1002/1873-3468.12906</a>. Beattie RJ, Hippenmeyer S. Mechanisms of radial glia progenitor cell lineage progression. <i>FEBS letters</i>. 2017;591(24):3993-4008. doi:<a href="https://doi.org/10.1002/1873-3468.12906">10.1002/1873-3468.12906</a> Beattie, R. J., &#38; Hippenmeyer, S. (2017). Mechanisms of radial glia progenitor cell lineage progression. <i>FEBS Letters</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/1873-3468.12906">https://doi.org/10.1002/1873-3468.12906</a> Beattie RJ, Hippenmeyer S. 2017. Mechanisms of radial glia progenitor cell lineage progression. FEBS letters. 591(24), 3993–4008. R. J. Beattie and S. Hippenmeyer, “Mechanisms of radial glia progenitor cell lineage progression,” <i>FEBS letters</i>, vol. 591, no. 24. Wiley-Blackwell, pp. 3993–4008, 2017. R.J. Beattie, S. Hippenmeyer, FEBS Letters 591 (2017) 3993–4008. 6212018-12-11T11:47:32Z2025-09-11T07:31:36Z