---
_id: '621'
abstract:
- lang: eng
  text: The mammalian cerebral cortex is responsible for higher cognitive functions
    such as perception, consciousness, and acquiring and processing information. The
    neocortex is organized into six distinct laminae, each composed of a rich diversity
    of cell types which assemble into highly complex cortical circuits. Radial glia
    progenitors (RGPs) are responsible for producing all neocortical neurons and certain
    glia lineages. Here, we discuss recent discoveries emerging from clonal lineage
    analysis at the single RGP cell level that provide us with an inaugural quantitative
    framework of RGP lineage progression. We further discuss the importance of the
    relative contribution of intrinsic gene functions and non-cell-autonomous or community
    effects in regulating RGP proliferation behavior and lineage progression.
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Robert J
  full_name: Beattie, Robert J
  id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
  last_name: Beattie
  orcid: 0000-0002-8483-8753
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Beattie RJ, Hippenmeyer S. Mechanisms of radial glia progenitor cell lineage
    progression. <i>FEBS letters</i>. 2017;591(24):3993-4008. doi:<a href="https://doi.org/10.1002/1873-3468.12906">10.1002/1873-3468.12906</a>
  apa: Beattie, R. J., &#38; Hippenmeyer, S. (2017). Mechanisms of radial glia progenitor
    cell lineage progression. <i>FEBS Letters</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/1873-3468.12906">https://doi.org/10.1002/1873-3468.12906</a>
  chicago: Beattie, Robert J, and Simon Hippenmeyer. “Mechanisms of Radial Glia Progenitor
    Cell Lineage Progression.” <i>FEBS Letters</i>. Wiley-Blackwell, 2017. <a href="https://doi.org/10.1002/1873-3468.12906">https://doi.org/10.1002/1873-3468.12906</a>.
  ieee: R. J. Beattie and S. Hippenmeyer, “Mechanisms of radial glia progenitor cell
    lineage progression,” <i>FEBS letters</i>, vol. 591, no. 24. Wiley-Blackwell,
    pp. 3993–4008, 2017.
  ista: Beattie RJ, Hippenmeyer S. 2017. Mechanisms of radial glia progenitor cell
    lineage progression. FEBS letters. 591(24), 3993–4008.
  mla: Beattie, Robert J., and Simon Hippenmeyer. “Mechanisms of Radial Glia Progenitor
    Cell Lineage Progression.” <i>FEBS Letters</i>, vol. 591, no. 24, Wiley-Blackwell,
    2017, pp. 3993–4008, doi:<a href="https://doi.org/10.1002/1873-3468.12906">10.1002/1873-3468.12906</a>.
  short: R.J. Beattie, S. Hippenmeyer, FEBS Letters 591 (2017) 3993–4008.
corr_author: '1'
date_created: 2018-12-11T11:47:32Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2025-09-11T07:31:36Z
day: '01'
ddc:
- '571'
- '610'
department:
- _id: SiHi
doi: 10.1002/1873-3468.12906
ec_funded: 1
external_id:
  isi:
  - '000418825700004'
  pmid:
  - '29121403'
file:
- access_level: open_access
  checksum: a46dadc84e0c28d389dd3e9e954464db
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:24Z
  date_updated: 2020-07-14T12:47:24Z
  file_id: '5211'
  file_name: IST-2018-928-v1+1_Beattie_et_al-2017-FEBS_Letters.pdf
  file_size: 644149
  relation: main_file
file_date_updated: 2020-07-14T12:47:24Z
has_accepted_license: '1'
intvolume: '       591'
isi: 1
issue: '24'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 3993  - 4008
pmid: 1
project:
- _id: 25D7962E-B435-11E9-9278-68D0E5697425
  grant_number: RGP0053/2014
  name: Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal
    Level
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618444'
  name: Molecular Mechanisms of Cerebral Cortex Development
publication: FEBS letters
publication_identifier:
  issn:
  - 0014-5793
publication_status: published
publisher: Wiley-Blackwell
publist_id: '7183'
pubrep_id: '928'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms of radial glia progenitor cell lineage progression
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 591
year: '2017'
...