--- res: bibo_abstract: - The plant hormone auxin has crucial roles in almost all aspects of plant growth and development. Concentrations of auxin vary across different tissues, mediating distinct developmental outcomes and contributing to the functional diversity of auxin. However, the mechanisms that underlie these activities are poorly understood. Here we identify an auxin signalling mechanism, which acts in parallel to the canonical auxin pathway based on the transport inhibitor response1 (TIR1) and other auxin receptor F-box (AFB) family proteins (TIR1/AFB receptors)1,2, that translates levels of cellular auxin to mediate differential growth during apical-hook development. This signalling mechanism operates at the concave side of the apical hook, and involves auxin-mediated C-terminal cleavage of transmembrane kinase 1 (TMK1). The cytosolic and nucleus-translocated C terminus of TMK1 specifically interacts with and phosphorylates two non-canonical transcriptional repressors of the auxin or indole-3-acetic acid (Aux/IAA) family (IAA32 and IAA34), thereby regulating ARF transcription factors. In contrast to the degradation of Aux/IAA transcriptional repressors in the canonical pathway, the newly identified mechanism stabilizes the non-canonical IAA32 and IAA34 transcriptional repressors to regulate gene expression and ultimately inhibit growth. The auxin–TMK1 signalling pathway originates at the cell surface, is triggered by high levels of auxin and shares a partially overlapping set of transcription factors with the TIR1/AFB signalling pathway. This allows distinct interpretations of different concentrations of cellular auxin, and thus enables this versatile signalling molecule to mediate complex developmental outcomes.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Min foaf_name: Cao, Min foaf_surname: Cao - foaf_Person: foaf_givenName: Rong foaf_name: Chen, Rong foaf_surname: Chen - foaf_Person: foaf_givenName: Pan foaf_name: Li, Pan foaf_surname: Li - foaf_Person: foaf_givenName: Yongqiang foaf_name: Yu, Yongqiang foaf_surname: Yu - foaf_Person: foaf_givenName: Rui foaf_name: Zheng, Rui foaf_surname: Zheng - foaf_Person: foaf_givenName: Danfeng foaf_name: Ge, Danfeng foaf_surname: Ge - foaf_Person: foaf_givenName: Wei foaf_name: Zheng, Wei foaf_surname: Zheng - foaf_Person: foaf_givenName: Xuhui foaf_name: Wang, Xuhui foaf_surname: Wang - foaf_Person: foaf_givenName: Yangtao foaf_name: Gu, Yangtao foaf_surname: Gu - foaf_Person: foaf_givenName: Zuzana foaf_name: Gelová, Zuzana foaf_surname: Gelová foaf_workInfoHomepage: http://www.librecat.org/personId=0AE74790-0E0B-11E9-ABC7-1ACFE5697425 orcid: 0000-0003-4783-1752 - foaf_Person: foaf_givenName: Jiří foaf_name: Friml, Jiří foaf_surname: Friml foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8302-7596 - foaf_Person: foaf_givenName: Heng foaf_name: Zhang, Heng foaf_surname: Zhang - foaf_Person: foaf_givenName: Renyi foaf_name: Liu, Renyi foaf_surname: Liu - foaf_Person: foaf_givenName: Jun foaf_name: He, Jun foaf_surname: He - foaf_Person: foaf_givenName: Tongda foaf_name: Xu, Tongda foaf_surname: Xu bibo_doi: 10.1038/s41586-019-1069-7 bibo_volume: 568 dct_date: 2019^xs_gYear dct_identifier: - UT:000464412700050 dct_isPartOf: - http://id.crossref.org/issn/0028-0836 - http://id.crossref.org/issn/1476-4687 dct_language: eng dct_publisher: Springer Nature@ dct_title: TMK1-mediated auxin signalling regulates differential growth of the apical hook@ fabio_hasPubmedId: '30944466' ...