---
res:
  bibo_abstract:
  - "Gravitropism is an adaptive response that orients plant growth parallel to the
    gravity vector. Asymmetric\r\ndistribution of the phytohormone auxin is a necessary
    prerequisite to the tropic bending both in roots and\r\nshoots. During hypocotyl
    gravitropic response, the PIN3 auxin transporter polarizes within gravity-sensing\r\ncells
    to redirect intercellular auxin fluxes. First gravity-induced PIN3 polarization
    to the bottom cell mem-\r\nbranes leads to the auxin accumulation at the lower
    side of the organ, initiating bending and, later, auxin\r\nfeedback-mediated repolarization
    restores symmetric auxin distribution to terminate bending. Here, we per-\r\nformed
    a forward genetic screen to identify regulators of both PIN3 polarization events
    during gravitropic\r\nresponse. We searched for mutants with defective PIN3 polarizations
    based on easy-to-score morphological\r\noutputs of decreased or increased gravity-induced
    hypocotyl bending. We identified the number of\r\nhypocotyl reduced bending (hrb)
    and hypocotyl hyperbending (hhb) mutants, revealing that reduced bending corre-\r\nlated
    typically with defective gravity-induced PIN3 relocation whereas all analyzed
    hhb mutants showed\r\ndefects in the second, auxin-mediated PIN3 relocation. Next-generation
    sequencing-aided mutation map-\r\nping identified several candidate genes, including
    SCARECROW and ACTIN2, revealing roles of endodermis\r\nspecification and actin
    cytoskeleton in the respective gravity- and auxin-induced PIN polarization events.\r\nThe
    hypocotyl gravitropism screen thus promises to provide novel insights into mechanisms
    underlying cell\r\npolarity and plant adaptive development.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Hana
      foaf_name: Rakusová, Hana
      foaf_surname: Rakusová
  - foaf_Person:
      foaf_givenName: Huibin
      foaf_name: Han, Huibin
      foaf_surname: Han
      foaf_workInfoHomepage: http://www.librecat.org/personId=31435098-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Petr
      foaf_name: Valošek, Petr
      foaf_surname: Valošek
      foaf_workInfoHomepage: http://www.librecat.org/personId=3CDB6F94-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Jiří
      foaf_name: Friml, Jiří
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  bibo_doi: 10.1111/tpj.14301
  bibo_issue: '6'
  bibo_volume: 98
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000473644100008
  dct_isPartOf:
  - http://id.crossref.org/issn/0960-7412
  - http://id.crossref.org/issn/1365-313x
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: Genetic screen for factors mediating PIN polarization in gravistimulated
    Arabidopsis thaliana hypocotyls@
  fabio_hasPubmedId: '30821050'
...