{"date_updated":"2021-01-12T08:07:08Z","series_title":"Advances in Anatomy Embryology and Cell Biology","author":[{"last_name":"Schroeder","first_name":"Jan","full_name":"Schroeder, Jan"},{"last_name":"Deliu","orcid":"0000-0002-7370-5293","id":"37A40D7E-F248-11E8-B48F-1D18A9856A87","first_name":"Elena","full_name":"Deliu, Elena"},{"full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia"},{"full_name":"Schmeisser, Michael","first_name":"Michael","last_name":"Schmeisser"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","editor":[{"first_name":"Michael","last_name":"Schmeisser","full_name":"Schmeisser, Michael"},{"full_name":"Boekers, Tobias","last_name":"Boekers","first_name":"Tobias"}],"year":"2017","_id":"634","alternative_title":["ADVSANAT"],"quality_controlled":"1","doi":"10.1007/978-3-319-52498-6_10","publication_status":"published","publication":"Translational Anatomy and Cell Biology of Autism Spectrum Disorder","month":"05","citation":{"ama":"Schroeder J, Deliu E, Novarino G, Schmeisser M. Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder. In: Schmeisser M, Boekers T, eds. <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i>. Vol 224. Advances in Anatomy Embryology and Cell Biology. Springer; 2017:189-211. doi:<a href=\"https://doi.org/10.1007/978-3-319-52498-6_10\">10.1007/978-3-319-52498-6_10</a>","chicago":"Schroeder, Jan, Elena Deliu, Gaia Novarino, and Michael Schmeisser. “Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder.” In <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i>, edited by Michael Schmeisser and Tobias Boekers, 224:189–211. Advances in Anatomy Embryology and Cell Biology. Springer, 2017. <a href=\"https://doi.org/10.1007/978-3-319-52498-6_10\">https://doi.org/10.1007/978-3-319-52498-6_10</a>.","apa":"Schroeder, J., Deliu, E., Novarino, G., &#38; Schmeisser, M. (2017). Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder. In M. Schmeisser &#38; T. Boekers (Eds.), <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i> (Vol. 224, pp. 189–211). Springer. <a href=\"https://doi.org/10.1007/978-3-319-52498-6_10\">https://doi.org/10.1007/978-3-319-52498-6_10</a>","ieee":"J. Schroeder, E. Deliu, G. Novarino, and M. Schmeisser, “Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder,” in <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i>, vol. 224, M. Schmeisser and T. Boekers, Eds. Springer, 2017, pp. 189–211.","short":"J. Schroeder, E. Deliu, G. Novarino, M. Schmeisser, in:, M. Schmeisser, T. Boekers (Eds.), Translational Anatomy and Cell Biology of Autism Spectrum Disorder, Springer, 2017, pp. 189–211.","ista":"Schroeder J, Deliu E, Novarino G, Schmeisser M. 2017.Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder. In: Translational Anatomy and Cell Biology of Autism Spectrum Disorder. ADVSANAT, vol. 224, 189–211.","mla":"Schroeder, Jan, et al. “Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder.” <i>Translational Anatomy and Cell Biology of Autism Spectrum Disorder</i>, edited by Michael Schmeisser and Tobias Boekers, vol. 224, Springer, 2017, pp. 189–211, doi:<a href=\"https://doi.org/10.1007/978-3-319-52498-6_10\">10.1007/978-3-319-52498-6_10</a>."},"volume":224,"scopus_import":1,"status":"public","date_created":"2018-12-11T11:47:37Z","language":[{"iso":"eng"}],"publication_identifier":{"eisbn":["978-3-319-52498-6"]},"title":"Genetic and pharmacological reversibility of phenotypes in mouse models of autism spectrum disorder","day":"28","page":"189 - 211","intvolume":"       224","project":[{"name":"Transmembrane Transporters in Health and Disease","grant_number":"F03523","_id":"25473368-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"type":"book_chapter","publist_id":"7156","publisher":"Springer","department":[{"_id":"GaNo"}],"date_published":"2017-05-28T00:00:00Z","oa_version":"None","abstract":[{"text":"As autism spectrum disorder (ASD) is largely regarded as a neurodevelopmental condition, long-time consensus was that its hallmark features are irreversible. However, several studies from recent years using defined mouse models of ASD have provided clear evidence that in mice neurobiological and behavioural alterations can be ameliorated or even reversed by genetic restoration or pharmacological treatment either before or after symptom onset. Here, we review findings on genetic and pharmacological reversibility of phenotypes in mouse models of ASD. Our review should give a comprehensive overview on both aspects and encourage future studies to better understand the underlying molecular mechanisms that might be translatable from animals to humans.","lang":"eng"}]}