---
res:
  bibo_abstract:
  - It has been reported that nicotinamide-overload induces oxidative stress associated
    with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This
    study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance
    tests (GTT) were carried out in adult Sprague-Dawley rats treated with or without
    cumulative doses of B vitamins. More specifically, insulin tolerance tests (ITT)
    were also carried out in adult Sprague-Dawley rats treated with or without cumulative
    doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration
    significantly increased the plasma H2O2 levels associated with high insulin levels.
    Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration
    of nicotinic acid, another form of Vitamin B3, also significantly increased plasma
    insulin level and H2O2 generation. Moreover, cumulative administration of nicotinic
    acid or nicotinamide impaired glucose metabolism. This study suggested that excess
    Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Wuping
      foaf_name: Sun, Wuping
      foaf_surname: Sun
  - foaf_Person:
      foaf_givenName: Ming-Zhu
      foaf_name: Zhai, Ming-Zhu
      foaf_surname: Zhai
      foaf_workInfoHomepage: http://www.librecat.org/personId=34009CFA-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Qian
      foaf_name: Zhou, Qian
      foaf_surname: Zhou
  - foaf_Person:
      foaf_givenName: Chengrui
      foaf_name: Qian, Chengrui
      foaf_surname: Qian
  - foaf_Person:
      foaf_givenName: Changyu
      foaf_name: Jiang, Changyu
      foaf_surname: Jiang
  bibo_doi: 10.4077/CJP.2017.BAF469
  bibo_issue: '4'
  bibo_volume: 60
  dct_date: 2017^xs_gYear
  dct_identifier:
  - UT:000409566300002
  dct_isPartOf:
  - http://id.crossref.org/issn/0304-4920
  dct_language: eng
  dct_publisher: Chinese Physiological Society@
  dct_title: Effects of B vitamins overload on plasma insulin level and hydrogen peroxide
    generation in rats@
  fabio_hasPubmedId: '28847140'
...