Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members Ortiz-Álvarez, G Daclin, M Shihavuddin, A Lansade, P Fortoul, A Faucourt, M Clavreul, S Lalioti, ME Taraviras, S Hippenmeyer, Simon ; https://orcid.org/0000-0003-2279-1061 Livet, J Meunier, A Genovesio, A Spassky, N ddc:570 Adult neural stem cells and multiciliated ependymalcells are glial cells essential for neurological func-tions. Together, they make up the adult neurogenicniche. Using both high-throughput clonal analysisand single-cell resolution of progenitor division pat-terns and fate, we show that these two componentsof the neurogenic niche are lineally related: adult neu-ral stem cells are sister cells to ependymal cells,whereas most ependymal cells arise from the termi-nal symmetric divisions of the lineage. Unexpectedly,we found that the antagonist regulators of DNA repli-cation, GemC1 and Geminin, can tune the proportionof neural stem cells and ependymal cells. Our find-ings reveal the controlled dynamic of the neurogenicniche ontogeny and identify the Geminin familymembers as key regulators of the initial pool of adultneural stem cells. Elsevier 2019 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/6454 https://research-explorer.ista.ac.at/download/6454/6457 Ortiz-Álvarez G, Daclin M, Shihavuddin A, et al. Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members. <i>Neuron</i>. 2019;102(1):159-172.e7. doi:<a href="https://doi.org/10.1016/j.neuron.2019.01.051">10.1016/j.neuron.2019.01.051</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2019.01.051 info:eu-repo/semantics/altIdentifier/issn/0896-6273 info:eu-repo/semantics/altIdentifier/e-issn/1097-4199 info:eu-repo/semantics/altIdentifier/wos/000463337900018 info:eu-repo/semantics/altIdentifier/pmid/30824354 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess