---
_id: '6454'
abstract:
- lang: eng
  text: 'Adult neural stem cells and multiciliated ependymalcells are glial cells
    essential for neurological func-tions. Together, they make up the adult neurogenicniche.
    Using both high-throughput clonal analysisand single-cell resolution of progenitor
    division pat-terns and fate, we show that these two componentsof the neurogenic
    niche are lineally related: adult neu-ral stem cells are sister cells to ependymal
    cells,whereas most ependymal cells arise from the termi-nal symmetric divisions
    of the lineage. Unexpectedly,we found that the antagonist regulators of DNA repli-cation,
    GemC1 and Geminin, can tune the proportionof neural stem cells and ependymal cells.
    Our find-ings reveal the controlled dynamic of the neurogenicniche ontogeny and
    identify the Geminin familymembers as key regulators of the initial pool of adultneural
    stem cells.'
article_processing_charge: No
author:
- first_name: G
  full_name: Ortiz-Álvarez, G
  last_name: Ortiz-Álvarez
- first_name: M
  full_name: Daclin, M
  last_name: Daclin
- first_name: A
  full_name: Shihavuddin, A
  last_name: Shihavuddin
- first_name: P
  full_name: Lansade, P
  last_name: Lansade
- first_name: A
  full_name: Fortoul, A
  last_name: Fortoul
- first_name: M
  full_name: Faucourt, M
  last_name: Faucourt
- first_name: S
  full_name: Clavreul, S
  last_name: Clavreul
- first_name: ME
  full_name: Lalioti, ME
  last_name: Lalioti
- first_name: S
  full_name: Taraviras, S
  last_name: Taraviras
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: J
  full_name: Livet, J
  last_name: Livet
- first_name: A
  full_name: Meunier, A
  last_name: Meunier
- first_name: A
  full_name: Genovesio, A
  last_name: Genovesio
- first_name: N
  full_name: Spassky, N
  last_name: Spassky
citation:
  ama: Ortiz-Álvarez G, Daclin M, Shihavuddin A, et al. Adult neural stem cells and
    multiciliated ependymal cells share a common lineage regulated by the Geminin
    family members. <i>Neuron</i>. 2019;102(1):159-172.e7. doi:<a href="https://doi.org/10.1016/j.neuron.2019.01.051">10.1016/j.neuron.2019.01.051</a>
  apa: Ortiz-Álvarez, G., Daclin, M., Shihavuddin, A., Lansade, P., Fortoul, A., Faucourt,
    M., … Spassky, N. (2019). Adult neural stem cells and multiciliated ependymal
    cells share a common lineage regulated by the Geminin family members. <i>Neuron</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.neuron.2019.01.051">https://doi.org/10.1016/j.neuron.2019.01.051</a>
  chicago: Ortiz-Álvarez, G, M Daclin, A Shihavuddin, P Lansade, A Fortoul, M Faucourt,
    S Clavreul, et al. “Adult Neural Stem Cells and Multiciliated Ependymal Cells
    Share a Common Lineage Regulated by the Geminin Family Members.” <i>Neuron</i>.
    Elsevier, 2019. <a href="https://doi.org/10.1016/j.neuron.2019.01.051">https://doi.org/10.1016/j.neuron.2019.01.051</a>.
  ieee: G. Ortiz-Álvarez <i>et al.</i>, “Adult neural stem cells and multiciliated
    ependymal cells share a common lineage regulated by the Geminin family members,”
    <i>Neuron</i>, vol. 102, no. 1. Elsevier, p. 159–172.e7, 2019.
  ista: Ortiz-Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M,
    Clavreul S, Lalioti M, Taraviras S, Hippenmeyer S, Livet J, Meunier A, Genovesio
    A, Spassky N. 2019. Adult neural stem cells and multiciliated ependymal cells
    share a common lineage regulated by the Geminin family members. Neuron. 102(1),
    159–172.e7.
  mla: Ortiz-Álvarez, G., et al. “Adult Neural Stem Cells and Multiciliated Ependymal
    Cells Share a Common Lineage Regulated by the Geminin Family Members.” <i>Neuron</i>,
    vol. 102, no. 1, Elsevier, 2019, p. 159–172.e7, doi:<a href="https://doi.org/10.1016/j.neuron.2019.01.051">10.1016/j.neuron.2019.01.051</a>.
  short: G. Ortiz-Álvarez, M. Daclin, A. Shihavuddin, P. Lansade, A. Fortoul, M. Faucourt,
    S. Clavreul, M. Lalioti, S. Taraviras, S. Hippenmeyer, J. Livet, A. Meunier, A.
    Genovesio, N. Spassky, Neuron 102 (2019) 159–172.e7.
date_created: 2019-05-14T13:06:30Z
date_published: 2019-04-03T00:00:00Z
date_updated: 2025-04-14T07:43:05Z
day: '03'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2019.01.051
ec_funded: 1
external_id:
  isi:
  - '000463337900018'
  pmid:
  - '30824354'
file:
- access_level: open_access
  checksum: 1fb6e195c583eb0c5cabf26f69ff6675
  content_type: application/pdf
  creator: dernst
  date_created: 2019-05-15T09:28:41Z
  date_updated: 2020-07-14T12:47:30Z
  file_id: '6457'
  file_name: 2019_Neuron_Ortiz.pdf
  file_size: 7288572
  relation: main_file
file_date_updated: 2020-07-14T12:47:30Z
has_accepted_license: '1'
intvolume: '       102'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '04'
oa: 1
oa_version: Published Version
page: 159-172.e7
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
  eissn:
  - 1097-4199
  issn:
  - 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adult neural stem cells and multiciliated ependymal cells share a common lineage
  regulated by the Geminin family members
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 102
year: '2019'
...