---
res:
  bibo_abstract:
  - During corticogenesis, distinct subtypes of neurons are sequentially born from
    ventricular zone progenitors. How these cells are molecularly temporally patterned
    is poorly understood. We used single-cell RNA sequencing at high temporal resolution
    to trace the lineage of the molecular identities of successive generations of
    apical progenitors (APs) and their daughter neurons in mouse embryos. We identified
    a core set of evolutionarily conserved, temporally patterned genes that drive
    APs from internally driven to more exteroceptive states. We found that the Polycomb
    repressor complex 2 (PRC2) epigenetically regulates AP temporal progression. Embryonic
    age–dependent AP molecular states are transmitted to their progeny as successive
    ground states, onto which essentially conserved early postmitotic differentiation
    programs are applied, and are complemented by later-occurring environment-dependent
    signals. Thus, epigenetically regulated temporal molecular birthmarks present
    in progenitors act in their postmitotic progeny to seed adult neuronal diversity.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: L
      foaf_name: Telley, L
      foaf_surname: Telley
  - foaf_Person:
      foaf_givenName: G
      foaf_name: Agirman, G
      foaf_surname: Agirman
  - foaf_Person:
      foaf_givenName: J
      foaf_name: Prados, J
      foaf_surname: Prados
  - foaf_Person:
      foaf_givenName: Nicole
      foaf_name: Amberg, Nicole
      foaf_surname: Amberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=4CD6AAC6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-3183-8207
  - foaf_Person:
      foaf_givenName: S
      foaf_name: Fièvre, S
      foaf_surname: Fièvre
  - foaf_Person:
      foaf_givenName: P
      foaf_name: Oberst, P
      foaf_surname: Oberst
  - foaf_Person:
      foaf_givenName: G
      foaf_name: Bartolini, G
      foaf_surname: Bartolini
  - foaf_Person:
      foaf_givenName: I
      foaf_name: Vitali, I
      foaf_surname: Vitali
  - foaf_Person:
      foaf_givenName: C
      foaf_name: Cadilhac, C
      foaf_surname: Cadilhac
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  - foaf_Person:
      foaf_givenName: L
      foaf_name: Nguyen, L
      foaf_surname: Nguyen
  - foaf_Person:
      foaf_givenName: A
      foaf_name: Dayer, A
      foaf_surname: Dayer
  - foaf_Person:
      foaf_givenName: D
      foaf_name: Jabaudon, D
      foaf_surname: Jabaudon
  bibo_doi: 10.1126/science.aav2522
  bibo_issue: '6440'
  bibo_volume: 364
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000467631800034
  dct_isPartOf:
  - http://id.crossref.org/issn/0036-8075
  - http://id.crossref.org/issn/1095-9203
  dct_language: eng
  dct_publisher: AAAS@
  dct_title: Temporal patterning of apical progenitors and their daughter neurons
    in the developing neocortex@
  fabio_hasPubmedId: '31073041'
...