---
_id: '6455'
abstract:
- lang: eng
  text: During corticogenesis, distinct subtypes of neurons are sequentially born
    from ventricular zone progenitors. How these cells are molecularly temporally
    patterned is poorly understood. We used single-cell RNA sequencing at high temporal
    resolution to trace the lineage of the molecular identities of successive generations
    of apical progenitors (APs) and their daughter neurons in mouse embryos. We identified
    a core set of evolutionarily conserved, temporally patterned genes that drive
    APs from internally driven to more exteroceptive states. We found that the Polycomb
    repressor complex 2 (PRC2) epigenetically regulates AP temporal progression. Embryonic
    age–dependent AP molecular states are transmitted to their progeny as successive
    ground states, onto which essentially conserved early postmitotic differentiation
    programs are applied, and are complemented by later-occurring environment-dependent
    signals. Thus, epigenetically regulated temporal molecular birthmarks present
    in progenitors act in their postmitotic progeny to seed adult neuronal diversity.
article_number: eaav2522
article_processing_charge: No
article_type: original
author:
- first_name: L
  full_name: Telley, L
  last_name: Telley
- first_name: G
  full_name: Agirman, G
  last_name: Agirman
- first_name: J
  full_name: Prados, J
  last_name: Prados
- first_name: Nicole
  full_name: Amberg, Nicole
  id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
  last_name: Amberg
  orcid: 0000-0002-3183-8207
- first_name: S
  full_name: Fièvre, S
  last_name: Fièvre
- first_name: P
  full_name: Oberst, P
  last_name: Oberst
- first_name: G
  full_name: Bartolini, G
  last_name: Bartolini
- first_name: I
  full_name: Vitali, I
  last_name: Vitali
- first_name: C
  full_name: Cadilhac, C
  last_name: Cadilhac
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: L
  full_name: Nguyen, L
  last_name: Nguyen
- first_name: A
  full_name: Dayer, A
  last_name: Dayer
- first_name: D
  full_name: Jabaudon, D
  last_name: Jabaudon
citation:
  ama: Telley L, Agirman G, Prados J, et al. Temporal patterning of apical progenitors
    and their daughter neurons in the developing neocortex. <i>Science</i>. 2019;364(6440).
    doi:<a href="https://doi.org/10.1126/science.aav2522">10.1126/science.aav2522</a>
  apa: Telley, L., Agirman, G., Prados, J., Amberg, N., Fièvre, S., Oberst, P., …
    Jabaudon, D. (2019). Temporal patterning of apical progenitors and their daughter
    neurons in the developing neocortex. <i>Science</i>. AAAS. <a href="https://doi.org/10.1126/science.aav2522">https://doi.org/10.1126/science.aav2522</a>
  chicago: Telley, L, G Agirman, J Prados, Nicole Amberg, S Fièvre, P Oberst, G Bartolini,
    et al. “Temporal Patterning of Apical Progenitors and Their Daughter Neurons in
    the Developing Neocortex.” <i>Science</i>. AAAS, 2019. <a href="https://doi.org/10.1126/science.aav2522">https://doi.org/10.1126/science.aav2522</a>.
  ieee: L. Telley <i>et al.</i>, “Temporal patterning of apical progenitors and their
    daughter neurons in the developing neocortex,” <i>Science</i>, vol. 364, no. 6440.
    AAAS, 2019.
  ista: Telley L, Agirman G, Prados J, Amberg N, Fièvre S, Oberst P, Bartolini G,
    Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D. 2019. Temporal
    patterning of apical progenitors and their daughter neurons in the developing
    neocortex. Science. 364(6440), eaav2522.
  mla: Telley, L., et al. “Temporal Patterning of Apical Progenitors and Their Daughter
    Neurons in the Developing Neocortex.” <i>Science</i>, vol. 364, no. 6440, eaav2522,
    AAAS, 2019, doi:<a href="https://doi.org/10.1126/science.aav2522">10.1126/science.aav2522</a>.
  short: L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fièvre, P. Oberst, G. Bartolini,
    I. Vitali, C. Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon, Science
    364 (2019).
date_created: 2019-05-14T13:07:47Z
date_published: 2019-05-10T00:00:00Z
date_updated: 2026-06-18T19:04:26Z
day: '10'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1126/science.aav2522
ec_funded: 1
external_id:
  isi:
  - '000467631800034'
  pmid:
  - '31073041'
fulldoi: https://doi.org/10.1126/science.aav2522
intvolume: '       364'
isi: 1
issue: '6440'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://orbi.uliege.be/bitstream/2268/239604/1/Telley_Agirman_Science2019.pdf
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 268F8446-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: T01031
  name: Role of Eed in neural stem cell lineage progression
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/how-to-generate-a-brain-of-correct-size-and-composition/
scopus_import: '1'
status: public
title: Temporal patterning of apical progenitors and their daughter neurons in the
  developing neocortex
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 364
year: '2019'
...