---
res:
  bibo_abstract:
  - The extent of heterogeneity among driver gene mutations present in naturally occurring
    metastases - that is, treatment-naive metastatic disease - is largely unknown.
    To address this issue, we carried out 60× whole-genome sequencing of 26 metastases
    from four patients with pancreatic cancer. We found that identical mutations in
    known driver genes were present in every metastatic lesion for each patient studied.
    Passenger gene mutations, which do not have known or predicted functional consequences,
    accounted for all intratumoral heterogeneity. Even with respect to these passenger
    mutations, our analysis suggests that the genetic similarity among the founding
    cells of metastases was higher than that expected for any two cells randomly taken
    from a normal tissue. The uniformity of known driver gene mutations among metastases
    in the same patient has critical and encouraging implications for the success
    of future targeted therapies in advanced-stage disease.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alvin
      foaf_name: Makohon Moore, Alvin
      foaf_surname: Makohon Moore
  - foaf_Person:
      foaf_givenName: Ming
      foaf_name: Zhang, Ming
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: Johannes
      foaf_name: Reiter, Johannes
      foaf_surname: Reiter
      foaf_workInfoHomepage: http://www.librecat.org/personId=4A918E98-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0170-7353
  - foaf_Person:
      foaf_givenName: Ivana
      foaf_name: Božić, Ivana
      foaf_surname: Božić
  - foaf_Person:
      foaf_givenName: Benjamin
      foaf_name: Allen, Benjamin
      foaf_surname: Allen
  - foaf_Person:
      foaf_givenName: Deepanjan
      foaf_name: Kundu, Deepanjan
      foaf_surname: Kundu
      foaf_workInfoHomepage: http://www.librecat.org/personId=1d4c0f4f-e8a3-11ec-a351-e36772758c45
  - foaf_Person:
      foaf_givenName: Krishnendu
      foaf_name: Chatterjee, Krishnendu
      foaf_surname: Chatterjee
      foaf_workInfoHomepage: http://www.librecat.org/personId=2E5DCA20-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4561-241X
  - foaf_Person:
      foaf_givenName: Fay
      foaf_name: Wong, Fay
      foaf_surname: Wong
  - foaf_Person:
      foaf_givenName: Yuchen
      foaf_name: Jiao, Yuchen
      foaf_surname: Jiao
  - foaf_Person:
      foaf_givenName: Zachary
      foaf_name: Kohutek, Zachary
      foaf_surname: Kohutek
  - foaf_Person:
      foaf_givenName: Jungeui
      foaf_name: Hong, Jungeui
      foaf_surname: Hong
  - foaf_Person:
      foaf_givenName: Marc
      foaf_name: Attiyeh, Marc
      foaf_surname: Attiyeh
  - foaf_Person:
      foaf_givenName: Breanna
      foaf_name: Javier, Breanna
      foaf_surname: Javier
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Wood, Laura
      foaf_surname: Wood
  - foaf_Person:
      foaf_givenName: Ralph
      foaf_name: Hruban, Ralph
      foaf_surname: Hruban
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Nowak, Martin
      foaf_surname: Nowak
  - foaf_Person:
      foaf_givenName: Nickolas
      foaf_name: Papadopoulos, Nickolas
      foaf_surname: Papadopoulos
  - foaf_Person:
      foaf_givenName: Kenneth
      foaf_name: Kinzler, Kenneth
      foaf_surname: Kinzler
  - foaf_Person:
      foaf_givenName: Bert
      foaf_name: Vogelstein, Bert
      foaf_surname: Vogelstein
  - foaf_Person:
      foaf_givenName: Christine
      foaf_name: Iacobuzio Donahue, Christine
      foaf_surname: Iacobuzio Donahue
  bibo_doi: 10.1038/ng.3764
  bibo_issue: '3'
  bibo_volume: 49
  dct_date: 2017^xs_gYear
  dct_identifier:
  - UT:000394917800009
  dct_isPartOf:
  - http://id.crossref.org/issn/1061-4036
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Limited heterogeneity of known driver gene mutations among the metastases
    of individual patients with pancreatic cancer@
  fabio_hasPubmedId: '28092682'
...