---
_id: '6601'
abstract:
- lang: eng
  text: There is increasing evidence that both mechanical and biochemical signals
    play important roles in development and disease. The development of complex organisms,
    in particular, has been proposed to rely on the feedback between mechanical and
    biochemical patterning events. This feedback occurs at the molecular level via
    mechanosensation but can also arise as an emergent property of the system at the
    cellular and tissue level. In recent years, dynamic changes in tissue geometry,
    flow, rheology, and cell fate specification have emerged as key platforms of mechanochemical
    feedback loops in multiple processes. Here, we review recent experimental and
    theoretical advances in understanding how these feedbacks function in development
    and disease.
article_processing_charge: No
article_type: review
author:
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Hannezo EB, Heisenberg C-PJ. Mechanochemical feedback loops in development
    and disease. <i>Cell</i>. 2019;178(1):12-25. doi:<a href="https://doi.org/10.1016/j.cell.2019.05.052">10.1016/j.cell.2019.05.052</a>
  apa: Hannezo, E. B., &#38; Heisenberg, C.-P. J. (2019). Mechanochemical feedback
    loops in development and disease. <i>Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.cell.2019.05.052">https://doi.org/10.1016/j.cell.2019.05.052</a>
  chicago: Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Mechanochemical Feedback
    Loops in Development and Disease.” <i>Cell</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.cell.2019.05.052">https://doi.org/10.1016/j.cell.2019.05.052</a>.
  ieee: E. B. Hannezo and C.-P. J. Heisenberg, “Mechanochemical feedback loops in
    development and disease,” <i>Cell</i>, vol. 178, no. 1. Elsevier, pp. 12–25, 2019.
  ista: Hannezo EB, Heisenberg C-PJ. 2019. Mechanochemical feedback loops in development
    and disease. Cell. 178(1), 12–25.
  mla: Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Mechanochemical Feedback
    Loops in Development and Disease.” <i>Cell</i>, vol. 178, no. 1, Elsevier, 2019,
    pp. 12–25, doi:<a href="https://doi.org/10.1016/j.cell.2019.05.052">10.1016/j.cell.2019.05.052</a>.
  short: E.B. Hannezo, C.-P.J. Heisenberg, Cell 178 (2019) 12–25.
date_created: 2019-06-30T21:59:11Z
date_published: 2019-07-27T00:00:00Z
date_updated: 2026-06-18T19:09:33Z
day: '27'
ddc:
- '570'
department:
- _id: CaHe
- _id: EdHa
doi: 10.1016/j.cell.2019.05.052
ec_funded: 1
external_id:
  isi:
  - '000473002700005'
  pmid:
  - '31251912'
intvolume: '       178'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cell.2019.05.052
month: '07'
oa: 1
oa_version: Published Version
page: 12-25
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742573'
  name: Interaction and feedback between cell mechanics and fate specification in
    vertebrate gastrulation
- _id: 268294B6-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P31639
  name: Active mechano-chemical description of the cell cytoskeleton
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanochemical feedback loops in development and disease
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 178
year: '2019'
...