---
res:
  bibo_abstract:
  - The molecular mechanisms underlying phenotypic variation in isogenic bacterial
    populations remain poorly understood.We report that AcrAB-TolC, the main multidrug
    efflux pump of Escherichia coli, exhibits a strong partitioning bias for old cell
    poles by a segregation mechanism that is mediated by ternary AcrAB-TolC complex
    formation. Mother cells inheriting old poles are phenotypically distinct and display
    increased drug efflux activity relative to daughters. Consequently, we find systematic
    and long-lived growth differences between mother and daughter cells in the presence
    of subinhibitory drug concentrations. A simple model for biased partitioning predicts
    a population structure of long-lived and highly heterogeneous phenotypes. This
    straightforward mechanism of generating sustained growth rate differences at subinhibitory
    antibiotic concentrations has implications for understanding the emergence of
    multidrug resistance in bacteria.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Tobias
      foaf_name: Bergmiller, Tobias
      foaf_surname: Bergmiller
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C471CFA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5396-4346
  - foaf_Person:
      foaf_givenName: Anna M
      foaf_name: Andersson, Anna M
      foaf_surname: Andersson
      foaf_workInfoHomepage: http://www.librecat.org/personId=2B8A40DA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2912-6769
  - foaf_Person:
      foaf_givenName: Kathrin
      foaf_name: Tomasek, Kathrin
      foaf_surname: Tomasek
      foaf_workInfoHomepage: http://www.librecat.org/personId=3AEC8556-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-3768-877X
  - foaf_Person:
      foaf_givenName: Enrique
      foaf_name: Balleza, Enrique
      foaf_surname: Balleza
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Kiviet, Daniel
      foaf_surname: Kiviet
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Hauschild, Robert
      foaf_surname: Hauschild
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E01D6B4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9843-3522
  - foaf_Person:
      foaf_givenName: Gasper
      foaf_name: Tkacik, Gasper
      foaf_surname: Tkacik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  bibo_doi: 10.1126/science.aaf4762
  bibo_issue: '6335'
  bibo_volume: 356
  dct_date: 2017^xs_gYear
  dct_identifier:
  - UT:000399540100060
  dct_isPartOf:
  - http://id.crossref.org/issn/0036-8075
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: Biased partitioning of the multidrug efflux pump AcrAB TolC underlies
    long lived phenotypic heterogeneity@
...