---
res:
  bibo_abstract:
  - 'Gene regulatory networks evolve through rewiring of individual components—that
    is, through changes in regulatory connections. However, the mechanistic basis
    of regulatory rewiring is poorly understood. Using a canonical gene regulatory
    system, we quantify the properties of transcription factors that determine the
    evolutionary potential for rewiring of regulatory connections: robustness, tunability
    and evolvability. In vivo repression measurements of two repressors at mutated
    operator sites reveal their contrasting evolutionary potential: while robustness
    and evolvability were positively correlated, both were in trade-off with tunability.
    Epistatic interactions between adjacent operators alleviated this trade-off. A
    thermodynamic model explains how the differences in robustness, tunability and
    evolvability arise from biophysical characteristics of repressor–DNA binding.
    The model also uncovers that the energy matrix, which describes how mutations
    affect repressor–DNA binding, encodes crucial information about the evolutionary
    potential of a repressor. The biophysical determinants of evolutionary potential
    for regulatory rewiring constitute a mechanistic framework for understanding network
    evolution.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Claudia
      foaf_name: Igler, Claudia
      foaf_surname: Igler
      foaf_workInfoHomepage: http://www.librecat.org/personId=46613666-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7777-546X
  - foaf_Person:
      foaf_givenName: Mato
      foaf_name: Lagator, Mato
      foaf_surname: Lagator
      foaf_workInfoHomepage: http://www.librecat.org/personId=345D25EC-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Gasper
      foaf_name: Tkacik, Gasper
      foaf_surname: Tkacik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  - foaf_Person:
      foaf_givenName: Jonathan P
      foaf_name: Bollback, Jonathan P
      foaf_surname: Bollback
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C6FA9CC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4624-4612
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  bibo_doi: 10.1038/s41559-018-0651-y
  bibo_issue: '10'
  bibo_volume: 2
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000447947600021
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Evolutionary potential of transcription factors for gene regulatory rewiring@
...