---
res:
  bibo_abstract:
  - Mathematical models have been used successfully at diverse scales of biological
    organization, ranging from ecology and population dynamics to stochastic reaction
    events occurring between individual molecules in single cells. Generally, many
    biological processes unfold across multiple scales, with mutations being the best
    studied example of how stochasticity at the molecular scale can influence outcomes
    at the population scale. In many other contexts, however, an analogous link between
    micro- and macro-scale remains elusive, primarily due to the challenges involved
    in setting up and analyzing multi-scale models. Here, we employ such a model to
    investigate how stochasticity propagates from individual biochemical reaction
    events in the bacterial innate immune system to the ecology of bacteria and bacterial
    viruses. We show analytically how the dynamics of bacterial populations are shaped
    by the activities of immunity-conferring enzymes in single cells and how the ecological
    consequences imply optimal bacterial defense strategies against viruses. Our results
    suggest that bacterial populations in the presence of viruses can either optimize
    their initial growth rate or their population size, with the first strategy favoring
    simple immunity featuring a single restriction modification system and the second
    strategy favoring complex bacterial innate immunity featuring several simultaneously
    active restriction modification systems.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jakob
      foaf_name: Ruess, Jakob
      foaf_surname: Ruess
      foaf_workInfoHomepage: http://www.librecat.org/personId=4A245D00-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1615-3282
  - foaf_Person:
      foaf_givenName: Maros
      foaf_name: Pleska, Maros
      foaf_surname: Pleska
      foaf_workInfoHomepage: http://www.librecat.org/personId=4569785E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7460-7479
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  - foaf_Person:
      foaf_givenName: Gašper
      foaf_name: Tkačik, Gašper
      foaf_surname: Tkačik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  bibo_doi: 10.1371/journal.pcbi.1007168
  bibo_issue: '7'
  bibo_volume: 15
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000481577700032
  dct_isPartOf:
  - http://id.crossref.org/issn/1553-7358
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_title: Molecular noise of innate immunity shapes bacteria-phage ecologies@
...