---
res:
  bibo_abstract:
  - "Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels control electrical
    rhythmicity and excitability in the heart and brain, but the function of HCN channels
    at the subcellular level in axons remains poorly understood. Here, we show that
    the action potential conduction velocity in both myelinated and unmyelinated central
    axons can be bidirectionally modulated by a HCN channel blocker, cyclic adenosine
    monophosphate (cAMP), and neuromodulators. Recordings from mouse cerebellar mossy
    fiber boutons show that HCN channels ensure reliable high-frequency firing and
    are strongly modulated by cAMP (EC50 40 mM; estimated endogenous cAMP concentration
    13 mM). In addition, immunogold-electron microscopy revealed HCN2 as the dominating
    subunit in cerebellar mossy fibers. Computational modeling indicated that HCN2
    channels control conduction velocity primarily by altering the resting membrane
    potential\r\nand are associated with significant metabolic costs. These results
    suggest that the cAMP-HCN pathway provides neuromodulators with an opportunity
    to finely tune energy consumption and temporal delays across axons in the brain.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Niklas
      foaf_name: Byczkowicz, Niklas
      foaf_surname: Byczkowicz
  - foaf_Person:
      foaf_givenName: Abdelmoneim
      foaf_name: Eshra, Abdelmoneim
      foaf_surname: Eshra
  - foaf_Person:
      foaf_givenName: Jacqueline-Claire
      foaf_name: Montanaro-Punzengruber, Jacqueline-Claire
      foaf_surname: Montanaro-Punzengruber
      foaf_workInfoHomepage: http://www.librecat.org/personId=3786AB44-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Andrea
      foaf_name: Trevisiol, Andrea
      foaf_surname: Trevisiol
  - foaf_Person:
      foaf_givenName: Johannes
      foaf_name: Hirrlinger, Johannes
      foaf_surname: Hirrlinger
  - foaf_Person:
      foaf_givenName: Maarten Hp
      foaf_name: Kole, Maarten Hp
      foaf_surname: Kole
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  - foaf_Person:
      foaf_givenName: Stefan
      foaf_name: Hallermann, Stefan
      foaf_surname: Hallermann
  bibo_doi: 10.7554/eLife.42766
  bibo_volume: 8
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000485663900001
  dct_isPartOf:
  - http://id.crossref.org/issn/2050-084X
  dct_language: eng
  dct_publisher: eLife Sciences Publications@
  dct_title: HCN channel-mediated neuromodulation can control action potential velocity
    and fidelity in central axons@
...