---
res:
  bibo_abstract:
  - Describing the protein interactions that form pleomorphic and asymmetric viruses
    represents a considerable challenge to most structural biology techniques, including
    X-ray crystallography and single particle cryo-electron microscopy. Obtaining
    a detailed understanding of these interactions is nevertheless important, considering
    the number of relevant human pathogens that do not follow strict icosahedral or
    helical symmetry. Cryo-electron tomography and subtomogram averaging methods provide
    structural insights into complex biological environments and are well suited to
    go beyond structures of perfectly symmetric viruses. This chapter discusses recent
    developments showing that cryo-ET and subtomogram averaging can provide high-resolution
    insights into hitherto unknown structural features of pleomorphic and asymmetric
    virus particles. It also describes how these methods have significantly added
    to our understanding of retrovirus capsid assemblies in immature and mature viruses.
    Additional examples of irregular viruses and their associated proteins, whose
    structures have been studied via cryo-ET and subtomogram averaging, further support
    the versatility of these methods.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Obr, Martin
      foaf_surname: Obr
      foaf_workInfoHomepage: http://www.librecat.org/personId=4741CA5A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1756-6564
  - foaf_Person:
      foaf_givenName: Florian KM
      foaf_name: Schur, Florian KM
      foaf_surname: Schur
      foaf_workInfoHomepage: http://www.librecat.org/personId=48AD8942-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4790-8078
  bibo_doi: 10.1016/bs.aivir.2019.07.008
  bibo_volume: 105
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000501594500006
  dct_isPartOf:
  - http://id.crossref.org/issn/0065-3527
  - http://id.crossref.org/issn/9780128184561
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Structural analysis of pleomorphic and asymmetric viruses using cryo-electron
    tomography and subtomogram averaging@
  fabio_hasPubmedId: '    31522703'
...