---
_id: '696'
abstract:
- lang: eng
  text: Mutator strains are expected to evolve when the availability and effect of
    beneficial mutations are high enough to counteract the disadvantage from deleterious
    mutations that will inevitably accumulate. As the population becomes more adapted
    to its environment, both availability and effect of beneficial mutations necessarily
    decrease and mutation rates are predicted to decrease. It has been shown that
    certain molecular mechanisms can lead to increased mutation rates when the organism
    finds itself in a stressful environment. While this may be a correlated response
    to other functions, it could also be an adaptive mechanism, raising mutation rates
    only when it is most advantageous. Here, we use a mathematical model to investigate
    the plausibility of the adaptive hypothesis. We show that such a mechanism can
    be mantained if the population is subjected to diverse stresses. By simulating
    various antibiotic treatment schemes, we find that combination treatments can
    reduce the effectiveness of second-order selection on stress-induced mutagenesis.
    We discuss the implications of our results to strategies of antibiotic therapy.
article_number: e1005609
article_processing_charge: No
article_type: original
author:
- first_name: Marta
  full_name: Lukacisinova, Marta
  id: 4342E402-F248-11E8-B48F-1D18A9856A87
  last_name: Lukacisinova
  orcid: 0000-0002-2519-8004
- first_name: Sebastian
  full_name: Novak, Sebastian
  id: 461468AE-F248-11E8-B48F-1D18A9856A87
  last_name: Novak
  orcid: 0000-0002-2519-824X
- first_name: Tiago
  full_name: Paixao, Tiago
  id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
  last_name: Paixao
  orcid: 0000-0003-2361-3953
citation:
  ama: 'Lukacisinova M, Novak S, Paixao T. Stress induced mutagenesis: Stress diversity
    facilitates the persistence of mutator genes. <i>PLoS Computational Biology</i>.
    2017;13(7). doi:<a href="https://doi.org/10.1371/journal.pcbi.1005609">10.1371/journal.pcbi.1005609</a>'
  apa: 'Lukacisinova, M., Novak, S., &#38; Paixao, T. (2017). Stress induced mutagenesis:
    Stress diversity facilitates the persistence of mutator genes. <i>PLoS Computational
    Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1005609">https://doi.org/10.1371/journal.pcbi.1005609</a>'
  chicago: 'Lukacisinova, Marta, Sebastian Novak, and Tiago Paixao. “Stress Induced
    Mutagenesis: Stress Diversity Facilitates the Persistence of Mutator Genes.” <i>PLoS
    Computational Biology</i>. Public Library of Science, 2017. <a href="https://doi.org/10.1371/journal.pcbi.1005609">https://doi.org/10.1371/journal.pcbi.1005609</a>.'
  ieee: 'M. Lukacisinova, S. Novak, and T. Paixao, “Stress induced mutagenesis: Stress
    diversity facilitates the persistence of mutator genes,” <i>PLoS Computational
    Biology</i>, vol. 13, no. 7. Public Library of Science, 2017.'
  ista: 'Lukacisinova M, Novak S, Paixao T. 2017. Stress induced mutagenesis: Stress
    diversity facilitates the persistence of mutator genes. PLoS Computational Biology.
    13(7), e1005609.'
  mla: 'Lukacisinova, Marta, et al. “Stress Induced Mutagenesis: Stress Diversity
    Facilitates the Persistence of Mutator Genes.” <i>PLoS Computational Biology</i>,
    vol. 13, no. 7, e1005609, Public Library of Science, 2017, doi:<a href="https://doi.org/10.1371/journal.pcbi.1005609">10.1371/journal.pcbi.1005609</a>.'
  short: M. Lukacisinova, S. Novak, T. Paixao, PLoS Computational Biology 13 (2017).
corr_author: '1'
date_created: 2018-12-11T11:47:58Z
date_published: 2017-07-18T00:00:00Z
date_updated: 2026-08-06T22:31:05Z
day: '18'
ddc:
- '576'
department:
- _id: ToBo
- _id: NiBa
- _id: CaGu
doi: 10.1371/journal.pcbi.1005609
ec_funded: 1
external_id:
  isi:
  - '000406619800014'
file:
- access_level: open_access
  checksum: 9143c290fa6458ed2563bff4b295554a
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:01Z
  date_updated: 2020-07-14T12:47:46Z
  file_id: '5117'
  file_name: IST-2017-894-v1+1_journal.pcbi.1005609.pdf
  file_size: 3775716
  relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
issue: '7'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618091'
  name: Speed of Adaptation in Population Genetics and Evolutionary Computation
publication: PLoS Computational Biology
publication_identifier:
  issn:
  - 1553-734X
publication_status: published
publisher: Public Library of Science
publist_id: '7004'
pubrep_id: '894'
quality_controlled: '1'
related_material:
  record:
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    status: public
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    relation: research_data
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  - id: '6263'
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    status: public
scopus_import: '1'
status: public
title: 'Stress induced mutagenesis: Stress diversity facilitates the persistence of
  mutator genes'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 13
year: '2017'
...