---
_id: '6980'
abstract:
- lang: eng
  text: Tissue morphogenesis in multicellular organisms is brought about by spatiotemporal
    coordination of mechanical and chemical signals. Extensive work on how mechanical
    forces together with the well‐established morphogen signalling pathways can actively
    shape living tissues has revealed evolutionary conserved mechanochemical features
    of embryonic development. More recently, attention has been drawn to the description
    of tissue material properties and how they can influence certain morphogenetic
    processes. Interestingly, besides the role of tissue material properties in determining
    how much tissues deform in response to force application, there is increasing
    theoretical and experimental evidence, suggesting that tissue material properties
    can abruptly and drastically change in development. These changes resemble phase
    transitions, pointing at the intriguing possibility that important morphogenetic
    processes in development, such as symmetry breaking and self‐organization, might
    be mediated by tissue phase transitions. In this review, we summarize recent findings
    on the regulation and role of tissue material properties in the context of the
    developing embryo. We posit that abrupt changes of tissue rheological properties
    may have important implications in maintaining the balance between robustness
    and adaptability during embryonic development.
article_number: e102497
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Nicoletta
  full_name: Petridou, Nicoletta
  id: 2A003F6C-F248-11E8-B48F-1D18A9856A87
  last_name: Petridou
  orcid: 0000-0002-8451-1195
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Petridou N, Heisenberg C-PJ. Tissue rheology in embryonic organization. <i>The
    EMBO Journal</i>. 2019;38(20). doi:<a href="https://doi.org/10.15252/embj.2019102497">10.15252/embj.2019102497</a>
  apa: Petridou, N., &#38; Heisenberg, C.-P. J. (2019). Tissue rheology in embryonic
    organization. <i>The EMBO Journal</i>. Embo Press. <a href="https://doi.org/10.15252/embj.2019102497">https://doi.org/10.15252/embj.2019102497</a>
  chicago: Petridou, Nicoletta, and Carl-Philipp J Heisenberg. “Tissue Rheology in
    Embryonic Organization.” <i>The EMBO Journal</i>. Embo Press, 2019. <a href="https://doi.org/10.15252/embj.2019102497">https://doi.org/10.15252/embj.2019102497</a>.
  ieee: N. Petridou and C.-P. J. Heisenberg, “Tissue rheology in embryonic organization,”
    <i>The EMBO Journal</i>, vol. 38, no. 20. Embo Press, 2019.
  ista: Petridou N, Heisenberg C-PJ. 2019. Tissue rheology in embryonic organization.
    The EMBO Journal. 38(20), e102497.
  mla: Petridou, Nicoletta, and Carl-Philipp J. Heisenberg. “Tissue Rheology in Embryonic
    Organization.” <i>The EMBO Journal</i>, vol. 38, no. 20, e102497, Embo Press,
    2019, doi:<a href="https://doi.org/10.15252/embj.2019102497">10.15252/embj.2019102497</a>.
  short: N. Petridou, C.-P.J. Heisenberg, The EMBO Journal 38 (2019).
corr_author: '1'
date_created: 2019-11-04T15:24:29Z
date_published: 2019-10-15T00:00:00Z
date_updated: 2025-05-14T11:21:32Z
day: '15'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.15252/embj.2019102497
ec_funded: 1
external_id:
  isi:
  - '000485561900001'
  pmid:
  - '31512749'
file:
- access_level: open_access
  checksum: 76f7f4e79ab6d850c30017a69726fd85
  content_type: application/pdf
  creator: dernst
  date_created: 2019-11-04T15:30:08Z
  date_updated: 2020-07-14T12:47:46Z
  file_id: '6981'
  file_name: 2019_Embo_Petridou.pdf
  file_size: 847356
  relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: '        38'
isi: 1
issue: '20'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742573'
  name: Interaction and feedback between cell mechanics and fate specification in
    vertebrate gastrulation
- _id: 2693FD8C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: V00736
  name: Tissue material properties in embryonic development
publication: The EMBO Journal
publication_identifier:
  eissn:
  - 1460-2075
  issn:
  - 0261-4189
publication_status: published
publisher: Embo Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tissue rheology in embryonic organization
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2019'
...